5-bromo-N-(4-fluorobenzyl)-2-hydroxyisophthalamic acid

Base Information

Chemical Name:5-bromo-N-(4-fluorobenzyl)-2-hydroxyisophthalamic acid
CAS No.:1289080-38-1
Molecular Formula:C₁₅H₁₁BrFNO₄
Molecular Weight:368.159
Hs Code.:

Synonyms:5-bromo-N-(4-fluorobenzyl)-2-hydroxyisophthalamic acid

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Chemical Property of 5-bromo-N-(4-fluorobenzyl)-2-hydroxyisophthalamic acid

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Technology Process of 5-bromo-N-(4-fluorobenzyl)-2-hydroxyisophthalamic acid

There total 4 articles about 5-bromo-N-(4-fluorobenzyl)-2-hydroxyisophthalamic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 1289079-29-3
5-bromo-N-(4-fluorobenzyl)-3-formyl-2-hydroxybenzamide

: 1289080-38-1
5-bromo-N-(4-fluorobenzyl)-2-hydroxyisophthalamic acid

Guidance literature:: With pyridine; potassium permanganate; In water; at 90 ℃;
DOI:10.1016/j.bmc.2011.01.047

Reference yield:

: 610-04-8
3-formylsalicylic acid

: 1289080-38-1
5-bromo-N-(4-fluorobenzyl)-2-hydroxyisophthalamic acid

Guidance literature:: Multi-step reaction with 3 steps

1: N-Bromosuccinimide / acetonitrile / 3 h / 20 °C

2: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / dichloromethane / 0 - 20 °C

3: pyridine; potassium permanganate / water / 90 °C

With pyridine; potassium permanganate; N-Bromosuccinimide; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In dichloromethane; water; acetonitrile;
DOI:10.1016/j.bmc.2011.01.047

Reference yield:

: 89-55-4
5-bromosalicyclic acid

: 1289080-38-1
5-bromo-N-(4-fluorobenzyl)-2-hydroxyisophthalamic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydroxide / water / 48 h / Reflux

1.2: pH 1

2.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / dichloromethane / 0 - 20 °C

3.1: pyridine; potassium permanganate / water / 90 °C

With pyridine; potassium permanganate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; sodium hydroxide; In dichloromethane; water; 1.1: Reimer-Tiemann reaction;
DOI:10.1016/j.bmc.2011.01.047