Elaeokanine B

Base Information

• Chemical Name: Elaeokanine B
• CAS No.: 33023-02-8
• Molecular Formula: C₁₂H₂₁NO
• Molecular Weight: 195.305
• Mol file: 33023-02-8.mol

Synonyms:8-Indolizinemethanol,1,2,3,5,6,8a-hexahydro-a-propyl-, [S-(R*,R*)]-; Eleokanine B (8CI); (-)-Elaeokanine B;(-)-Eleokanine B; Elaeokanin B; Elaeokanine B

Chemical Property of Elaeokanine B

Chemical Property:

• PSA: 23.47000
• LogP: 1.87980

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Elaeokanine B

There total 37 articles about Elaeokanine B which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

(8S,8aS,1'S,SS)-8-(1-hydroxybutyl)-1,2,3,5,6,7,8,8a-octahydro-8-<(4-methylphenyl)sulfinyl>indolizine (125475-14-1) → (-)-Elaeokanine B (33023-02-8)

Guidance literature:

With triethylamine; In ethanol; for 2h; Heating;

DOI:10.1021/jo00294a028

Reference yield: 91.0%

1,5,6,8a-tetrahydro-8-(1-hydroxybutyl)-3(2H)-indolizinone (73971-35-4) → elaeokanine B (33023-02-8)

Guidance literature:

With diisobutylaluminium hydride; In tetrahydrofuran; hexane; for 0.5h; Ambient temperature;

DOI:10.1021/ja00411a020

Reference yield: 90.0%

(8R,8aS,1'S,SS)-8-(1-hydroxybutyl)-1,2,3,5,6,7,8,8a-octahydro-8-<(4-methylphenyl)sulfinyl>indolizine (125517-34-2) → (-)-Elaeokanine B (33023-02-8)

Guidance literature:

With triethylamine; In ethanol; Heating;

DOI:10.1021/jo00294a028

upstream raw materials:

n-propylmagnesium bromide

1,2,3,5,6,8a-Hexahydro-indolizine-8-carbaldehyde

1,5,6,8a-tetrahydro-8-(1-hydroxybutyl)-3(2H)-indolizinone

butyraldehyde