Technology Process of (2-Carboxy-ethyl)-diphenyl-((E)-tridec-2-ene-4,7-diynyl)-phosphonium; bromide
There total 6 articles about (2-Carboxy-ethyl)-diphenyl-((E)-tridec-2-ene-4,7-diynyl)-phosphonium; bromide which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 5 steps
1: toluenesulfonic acid / 1 h / 0 °C
2: 1.) C2H5MgBr, 2.)CuBr / 1.) THF, 20 deg C, 2.) 60 deg C, 45 min
3: 0.5 N H2SO4 / acetone / 3 h / 20 °C
4: 63 percent / PBr3, 5percent pyridine / diethyl ether / 18 h / 20 °C
5: 50 percent / diethyl ether / 48 h / 20 °C
With
pyridine; sulfuric acid; o-toluenesulfonic acid; ethylmagnesium bromide; phosphorus tribromide; copper(I) bromide;
In
diethyl ether; acetone;
DOI:10.1016/0040-4039(88)85088-3
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 1.) C2H5MgBr, 2.)CuBr / 1.) THF, 20 deg C, 2.) 60 deg C, 45 min
2: 0.5 N H2SO4 / acetone / 3 h / 20 °C
3: 63 percent / PBr3, 5percent pyridine / diethyl ether / 18 h / 20 °C
4: 50 percent / diethyl ether / 48 h / 20 °C
With
pyridine; sulfuric acid; ethylmagnesium bromide; phosphorus tribromide; copper(I) bromide;
In
diethyl ether; acetone;
DOI:10.1016/0040-4039(88)85088-3
