3-(Diphenylphosphino)propionic acid

Base Information

• Chemical Name: 3-(Diphenylphosphino)propionic acid
• CAS No.: 2848-01-3
• Molecular Formula: C15H15O2P
• Molecular Weight: 258.257
• Hs Code.: 2931900090
• European Community (EC) Number: 686-946-0
• DSSTox Substance ID: DTXSID40395341
• Nikkaji Number: J2.480.966H
• Wikidata: Q82195379
• Mol file: 2848-01-3.mol

Synonyms:3-(DIPHENYLPHOSPHINO)PROPIONIC ACID;2848-01-3;3-(diphenylphosphino)-propanoic acid;3-diphenylphosphanylpropanoic Acid;Propanoic acid, 3-(diphenylphosphino)-;3-(diphenylphosphanyl)propanoic acid;(2-Carboxyethyl)diphenylphosphine;3-(diphenylphosphino)propanoic acid;SCHEMBL1095111;DTXSID40395341;OTSIFUHGOBFOTH-UHFFFAOYSA-N;3-(diphenylphosphino)-propanoicacid;MFCD00775376;STK372992;AKOS005447164;3-(Diphenylphosphino)propionic acid, 97%;CS-0199074;10.14272/OTSIFUHGOBFOTH-UHFFFAOYSA-N;E76931;doi:10.14272/OTSIFUHGOBFOTH-UHFFFAOYSA-N;J-017105

Chemical Property of 3-(Diphenylphosphino)propionic acid

Chemical Property:

• Melting Point: 130-134°C
• Boiling Point: 151 °C(Press: 0.4 Torr)
• PKA: 4.50±0.10(Predicted)
• PSA: 50.89000
• LogP: 2.59400
• XLogP3: 2.5
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 5
• Exact Mass: 258.08096671
• Heavy Atom Count: 18
• Complexity: 237

Purity/Quality:

97% ^*data from raw suppliers

3-(Diphenylphosphino)propionic acid 97% ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)P(CCC(=O)O)C2=CC=CC=C2
• Uses: Reactant for:Organocatalytic asymmetric aziridination of imines and diazo compoundsPhosphine-mediated conversion of azides into diazo compoundsPreparation of rhodium catalysts for hydroformylationSynthesis of reagents for the Mitsunobu reaction

Technology Process of 3-(Diphenylphosphino)propionic acid

There total 17 articles about 3-(Diphenylphosphino)propionic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.5%

diphenylphosphane (829-85-6) + ethyl acrylate (140-88-5,9003-32-1) → 3-(diphenylphosphino)propionic acid (2848-01-3)

Guidance literature:

diphenylphosphane; ethyl acrylate; In acetonitrile; at -20 - 25 ℃; Inert atmosphere;

With potassium hydroxide; In acetonitrile;

Reference yield: 98.4%

acrylic acid methyl ester (292638-85-8,9003-21-8,96-33-3) + diphenylphosphane (829-85-6) → 3-(diphenylphosphino)propionic acid (2848-01-3)

Guidance literature:

acrylic acid methyl ester; diphenylphosphane; In acetonitrile; at -20 - 25 ℃; Inert atmosphere;

With potassium hydroxide; In acetonitrile;

Reference yield: 94.0%

ethyl 3-chloropropanoate (623-71-2) + diphenylphosphane (829-85-6) → 3-(diphenylphosphino)propionic acid (2848-01-3)

Guidance literature:

With potassium hydroxide; In dimethyl sulfoxide; at 50 - 55 ℃; for 2h;

DOI:10.1055/s-1986-31510

upstream raw materials:

(2-cyanoethyl)diphenylphosphine

β-Propiolactone

diphenylphosphane

diphenylphosphinosuccinic acid

Downstream raw materials:

(β-benzoylethyl)diphenylphosphine oxide

(2-Carboxy-ethyl)-diphenyl-((E)-tridec-2-ene-4,7-diynyl)-phosphonium; bromide

3-(diphenylphosphorothioyl)propionic acid

3-(phenylphosphino)propanoic acid