N-(4-(3-(pyrrolidin-1-yl)propanamido)phenyl)-2-(1,2-dihydro-2,4-dioxoquinazolin-3(4H)-yl)benzamide

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Chemical Name:N-(4-(3-(pyrrolidin-1-yl)propanamido)phenyl)-2-(1,2-dihydro-2,4-dioxoquinazolin-3(4H)-yl)benzamide
CAS No.:1070977-98-8
Molecular Formula:C₂₈H₂₇N₅O₄
Molecular Weight:497.553
Hs Code.:

Synonyms:N-(4-(3-(pyrrolidin-1-yl)propanamido)phenyl)-2-(1,2-dihydro-2,4-dioxoquinazolin-3(4H)-yl)benzamide

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Chemical Property of N-(4-(3-(pyrrolidin-1-yl)propanamido)phenyl)-2-(1,2-dihydro-2,4-dioxoquinazolin-3(4H)-yl)benzamide

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Technology Process of N-(4-(3-(pyrrolidin-1-yl)propanamido)phenyl)-2-(1,2-dihydro-2,4-dioxoquinazolin-3(4H)-yl)benzamide

There total 8 articles about N-(4-(3-(pyrrolidin-1-yl)propanamido)phenyl)-2-(1,2-dihydro-2,4-dioxoquinazolin-3(4H)-yl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 393570-64-4
N-(4-amino-phenyl)-3-(pyrrolidin-1-yl)-propionamide

: 4471-39-0
N,N'-Di(2-carboxyphenyl)urea

: 1070977-98-8
N-(4-(3-(pyrrolidin-1-yl)propanamido)phenyl)-2-(1,2-dihydro-2,4-dioxoquinazolin-3(4H)-yl)benzamide

Guidance literature:: With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; In N,N-dimethyl-formamide; at 20 ℃; for 22h;

Reference yield:

: 851651-95-1
N-(4-nitro-phenyl)-3-(pyrrolidin-1-yl)-propionamide

: 1070977-98-8
N-(4-(3-(pyrrolidin-1-yl)propanamido)phenyl)-2-(1,2-dihydro-2,4-dioxoquinazolin-3(4H)-yl)benzamide

Guidance literature:: Multi-step reaction with 2 steps

1: ammonium formate / palladium on activated charcoal / methanol / 20 °C

2: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate / N,N-dimethyl-formamide / 22 h / 20 °C

With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; ammonium formate; palladium on activated charcoal; In methanol; N,N-dimethyl-formamide;

Reference yield:

: 552-16-9,104810-18-6
ortho-nitrobenzoic acid

: 1070977-98-8
N-(4-(3-(pyrrolidin-1-yl)propanamido)phenyl)-2-(1,2-dihydro-2,4-dioxoquinazolin-3(4H)-yl)benzamide

Guidance literature:: Multi-step reaction with 5 steps

1: dmap; dicyclohexyl-carbodiimide / dichloromethane / 4 h / 0 - 20 °C

2: hydrogen / palladium on activated charcoal / methanol / 3.5 h

3: tetrahydrofuran / 48 h / Heating / reflux

4: trifluoroacetic acid / 1 h / 20 °C

5: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate / N,N-dimethyl-formamide / 22 h / 20 °C

With dmap; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; hydrogen; dicyclohexyl-carbodiimide; trifluoroacetic acid; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;