4471-39-0

Usage

Uses

Used in Pharmaceutical Industry:
2-[(2-carboxyphenyl)carbamoyl]aminobenzoic acid is used as a pharmaceutical compound for its potential therapeutic applications. Its antioxidant and anti-inflammatory properties make it a promising candidate for the development of new drugs to treat various diseases and conditions.
Used in Organic Synthesis:
2-[(2-carboxyphenyl)carbamoyl]aminobenzoic acid is used as a building block in the synthesis of other organic compounds. Its unique structure and functional groups allow for the creation of new molecules with potential applications in various industries, including pharmaceuticals, materials science, and agrochemicals.
Used in Antioxidant and Anti-inflammatory Applications:
2-[(2-carboxyphenyl)carbamoyl]aminobenzoic acid is used as an antioxidant and anti-inflammatory agent. Its ability to neutralize free radicals and reduce inflammation may contribute to the prevention and treatment of various diseases and conditions, such as cardiovascular diseases, neurodegenerative disorders, and inflammatory conditions.
Used in Research and Development:
2-[(2-carboxyphenyl)carbamoyl]aminobenzoic acid is used as a research compound for further investigation of its properties and potential applications. Its unique structure and functional groups make it an interesting subject for studies in the fields of medicine and organic chemistry, with the aim of discovering new therapeutic agents and synthetic pathways.

Upstream product

• 75-52-5 nitromethane 
• 5100-23-2 2-isocyanatobenzoyl chloride 
• 13969-02-3 5H,12H-Quinazolino<3,2-a><3,1>benzoxazine-5,12-dione 
• 118-48-9 isatoic anhydride 
• 1070978-96-9 2,2'-ureylene-di-(tert-butylbenzoate) 
• 552-16-9 ortho-nitrobenzoic acid 
• 55666-41-6 tert-butyl 2-nitrobenzoate 

Downstream Products

• 122-39-4 diphenylamine 
• 62-53-3 aniline 
• 1070977-98-8 N-(4-(3-(pyrrolidin-1-yl)propanamido)phenyl)-2-(1,2-dihydro-2,4-dioxoquinazolin-3(4H)-yl)benzamide 
• 1070978-04-9 N-(3-(3-(pyrrolidin-1-yl)propanamido)phenyl)-2-(1,2-dihydro-2,4-dioxoquinazolin-3(4H)-yl)benzamide 
• 1070978-02-7 N-(3-(2-(pyrrolidin-1-yl)acetamido)phenyl)-2-(1,2-dihydro-2,4-dioxoquinazolin-3(4H)-yl)benzamide 
• 1070977-96-6 N-(4-(2-(pyrrolidin-1-yl)acetamido)phenyl)-2-(1,2-dihydro-2,4-dioxoquinazolin-3(4H)-yl)benzamide 
• 1070978-00-5 N-(4-(4-(pyrrolidin-1-yl)butanamido)phenyl)-2-(1,2-dihydro-2,4-dioxoquinazolin-3(4H)-yl)benzamide 
• 1070978-06-1 N-(3-(4-(pyrrolidin-1-yl)butanamido)phenyl)-2-(1,2-dihydro-2,4-dioxoquinazolin-3(4H)-yl)benzamide 
• 13905-97-0 3-(2-Carbomethoxyphenyl)-1,2,3,4-tetrahydroquinazoline-2,4-dione 

Relevant academic research and scientific papers

UREYLENE DERIVATIVES

The invention concerns compounds of Formula (I) or a salt, solvate or pro-drug thereof. The compounds may be used in therapy, particularly anti-cancer therapy.

Rational design of substituted diarylureas: A scaffold for binding to G-quadruplex motifs

The design and synthesis of a series of urea-based nonpolycyclic aromatic ligands with alkylaminoanilino side chains as telomeric and genomic G-quadruplex DNA interacting agents are described. Their interactions with quadruplexes have been examined by means of fluorescent resonance energy transfer melting, circular dichroism, and surface plasmon resonance-based assays. These validate the design concept for such urea-based ligands and also show that they have significant selectivity over duplex DNA, as well as for particular G-quadruplexes. The ligand-quadruplex complexes were investigated by computational molecular modeling, providing further information on structure-activity relationships. Preliminary biological studies using short-term cell growth inhibition assays show that some of the ligands have cancer cell selectivity, although they appear to have low potency for intracellular telomeric G-quadruplex structures, suggesting that their cellular targets may be other, possibly oncogene-related quadruplexes.

A New Synthesis of 5H,12H-Quinazolinobenzoxazine-5,12-dione

5H,12H-Quinazolinobenzoxazine-5,12-dione (2) is obtained by reaction of nitromethane with 2-isocyanatobenzoyl chloride (1) at room temperature in the presence of anhyd. sodium carbonate.A suitable mechanism has been proposed for its formation.