N²-(benzyloxycarbonyl)-N⁵-(benzyloxy)-N⁵-(allyloxycarbonyl)-L-ornithine 1-tert-butyl ester

Base Information

• Chemical Name: N²-(benzyloxycarbonyl)-N⁵-(benzyloxy)-N⁵-(allyloxycarbonyl)-L-ornithine 1-tert-butyl ester
• CAS No.: 131618-12-7
• Molecular Formula: C₂₈H₃₆N₂O₇
• Molecular Weight: 512.603

Synonyms:N²-(benzyloxycarbonyl)-N⁵-(benzyloxy)-N⁵-(allyloxycarbonyl)-L-ornithine 1-tert-butyl ester

Chemical Property of N²-(benzyloxycarbonyl)-N⁵-(benzyloxy)-N⁵-(allyloxycarbonyl)-L-ornithine 1-tert-butyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N²-(benzyloxycarbonyl)-N⁵-(benzyloxy)-N⁵-(allyloxycarbonyl)-L-ornithine 1-tert-butyl ester

There total 2 articles about N²-(benzyloxycarbonyl)-N⁵-(benzyloxy)-N⁵-(allyloxycarbonyl)-L-ornithine 1-tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-benzyloxyamine (622-33-3) → N2-(benzyloxycarbonyl)-N5-(benzyloxy)-N5-(allyloxycarbonyl)-L-ornithine 1-tert-butyl ester (131618-12-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 96 percent / pyridine / CH₂Cl₂ / 1 h

2: triphenylphosphine, diethyl azodicarboxylate / tetrahydrofuran / 13 h / Ambient temperature

With pyridine; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; dichloromethane;

DOI:10.1021/jo00002a005

Reference yield:

N2-(benzyloxycarbonyl)-N5-(benzyloxy)-N5-<(2,2,2-trichloroethoxy)carbonyl>-L-ornithine 1-tert-butyl ester (124620-52-6) + Allyl chloroformate (2937-50-0) → (S)-5-Allyloxycarbonylamino-2-benzyloxycarbonylamino-pentanoic acid tert-butyl ester (131618-13-8) + N2-(benzyloxycarbonyl)-N5-(benzyloxy)-N5-(allyloxycarbonyl)-L-ornithine 1-tert-butyl ester (131618-12-7)

Guidance literature:

With potassium hydrogencarbonate; acetic acid; zinc; Yield given. Multistep reaction. Yields of byproduct given; 1.) sonication, 2h, 2.) THF, H₂O, overnight;

DOI:10.1021/jo00002a005

Reference yield:

N2-(benzyloxycarbonyl)-N5-(benzyloxy)-N5-(allyloxycarbonyl)-L-ornithine 1-tert-butyl ester (131618-12-7) → (3S,6S)-3-<3-propyl>-6-<3-propyl>-2,5-piperazinedione (131618-19-4)

Guidance literature:

Multi-step reaction with 4 steps

1: CF₃COOH / CH₂Cl₂ / 1 h

2: Et₃N, EEDQ / CH₂Cl₂

3: 28 percent / 30percent HBr-HOAc / CH₂Cl₂ / 0.17 h

4: 70 percent / imidazole / methanol / 96 h

With 1H-imidazole; hydrogen bromide; acetic acid; N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline; triethylamine; trifluoroacetic acid; In methanol; dichloromethane;

DOI:10.1021/jo00002a005

upstream raw materials:

N²-(benzyloxycarbonyl)-N⁵-(benzyloxy)-N⁵-<(2,2,2-trichloroethoxy)carbonyl>-L-ornithine 1-tert-butyl ester

Allyl chloroformate

N-benzyloxyamine

Downstream raw materials:

(3S,6S)-3-<3-propyl>-6-<3-propyl>-2,5-piperazinedione

(3S,6S)-3-<3-propyl>-6-<3-propyl>-2,5-piperazinedione

N²-5-(benzyloxy)-L-ornithinyl>-N⁵-(benzyloxy)-N⁵-(2,2,2-trichloroethoxycarbonyl)-L-ornithine 1-methyl ester

(3S,6S)-3-<3-propyl>-6-<3-propyl>-2,5-piperazinedione

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 131618-12-7 N²-(benzyloxycarbonyl)-N⁵-(benzyloxy)-N⁵-(allyloxycarbonyl)-L-ornithine 1-tert-butyl ester

Send

Send

Metric Ton KG G Pound L ML

Send

Send