tert-butyl 1-[4-(methoxycarbonyl)phenylcarbonyl]isoquinolin-4-yloxyacetate

Base Information

Chemical Name:tert-butyl 1-[4-(methoxycarbonyl)phenylcarbonyl]isoquinolin-4-yloxyacetate
CAS No.:1374249-69-0
Molecular Formula:C₂₄H₂₃NO₆
Molecular Weight:421.45
Hs Code.:

Synonyms:tert-butyl 1-[4-(methoxycarbonyl)phenylcarbonyl]isoquinolin-4-yloxyacetate

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Chemical Property of tert-butyl 1-[4-(methoxycarbonyl)phenylcarbonyl]isoquinolin-4-yloxyacetate

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Technology Process of tert-butyl 1-[4-(methoxycarbonyl)phenylcarbonyl]isoquinolin-4-yloxyacetate

There total 6 articles about tert-butyl 1-[4-(methoxycarbonyl)phenylcarbonyl]isoquinolin-4-yloxyacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 5292-43-3
bromoacetic acid tert-butyl ester

: 1374249-68-9
4-hydroxy-1-{4-(methoxycarbonyl)phenylcarbonyl}isoquinoline

: 1374249-69-0
tert-butyl 1-[4-(methoxycarbonyl)phenylcarbonyl]isoquinolin-4-yloxyacetate

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃;
DOI:10.1016/j.bmcl.2012.03.009

Reference yield:

: 66728-98-1
4-bromo-1-chloroisoqionoline

: 1374249-69-0
tert-butyl 1-[4-(methoxycarbonyl)phenylcarbonyl]isoquinolin-4-yloxyacetate

Guidance literature:: Multi-step reaction with 4 steps

1: sodium hexamethyldisilazane / tetrahydrofuran / 0 - 20 °C

2: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate / 80 °C

3: ; sodium hydrogencarbonate / water; acetone / 0 - 20 °C

4: potassium carbonate / N,N-dimethyl-formamide / 20 °C

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate; sodium hexamethyldisilazane; sodium hydrogencarbonate; potassium carbonate; In tetrahydrofuran; water; N,N-dimethyl-formamide; acetone;
DOI:10.1016/j.bmcl.2012.03.009

Reference yield:

: 1374249-66-7
4-bromo-1-{4-(methoxycarbonyl)phenylcarbonyl}isoquinoline

: 1374249-69-0
tert-butyl 1-[4-(methoxycarbonyl)phenylcarbonyl]isoquinolin-4-yloxyacetate

Guidance literature:: Multi-step reaction with 3 steps

1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate / 80 °C

2: ; sodium hydrogencarbonate / water; acetone / 0 - 20 °C

3: potassium carbonate / N,N-dimethyl-formamide / 20 °C

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate; sodium hydrogencarbonate; potassium carbonate; In water; N,N-dimethyl-formamide; acetone;
DOI:10.1016/j.bmcl.2012.03.009