(1R,2S)-(E)-5'-methoxy-2-(3-(4-(2-morpholinoethyl)styryl)-1H-indazol-6-yl)spiro(cyclopropane-1,3'-indolin)-2'-one 2,2,2-trifluoroacetate

Base Information

Chemical Name:(1R,2S)-(E)-5'-methoxy-2-(3-(4-(2-morpholinoethyl)styryl)-1H-indazol-6-yl)spiro(cyclopropane-1,3'-indolin)-2'-one 2,2,2-trifluoroacetate
CAS No.:1338806-02-2
Molecular Formula:C₂HF₃O₂*C₃₂H₃₂N₄O₃
Molecular Weight:634.655
Hs Code.:

Synonyms:(1R,2S)-(E)-5'-methoxy-2-(3-(4-(2-morpholinoethyl)styryl)-1H-indazol-6-yl)spiro(cyclopropane-1,3'-indolin)-2'-one 2,2,2-trifluoroacetate

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Chemical Property of (1R,2S)-(E)-5'-methoxy-2-(3-(4-(2-morpholinoethyl)styryl)-1H-indazol-6-yl)spiro(cyclopropane-1,3'-indolin)-2'-one 2,2,2-trifluoroacetate

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Technology Process of (1R,2S)-(E)-5'-methoxy-2-(3-(4-(2-morpholinoethyl)styryl)-1H-indazol-6-yl)spiro(cyclopropane-1,3'-indolin)-2'-one 2,2,2-trifluoroacetate

There total 4 articles about (1R,2S)-(E)-5'-methoxy-2-(3-(4-(2-morpholinoethyl)styryl)-1H-indazol-6-yl)spiro(cyclopropane-1,3'-indolin)-2'-one 2,2,2-trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1247002-61-4
(1R,2S)-(E)-5'-methoxy-2-(3-(4-(2-morpholinoethyl)styryl)-1H-indazol-6-yl)spiro(cyclopropane-1,3'-indolin)-2'-one

: 76-05-1
trifluoroacetic acid

: 1338806-02-2
(1R,2S)-(E)-5'-methoxy-2-(3-(4-(2-morpholinoethyl)styryl)-1H-indazol-6-yl)spiro(cyclopropane-1,3'-indolin)-2'-one 2,2,2-trifluoroacetate

Guidance literature:: In water; acetonitrile;

Reference yield:

: 736991-39-2
4-[2-(4-bromophenyl)ethyl]morpholine

: 1338806-02-2
(1R,2S)-(E)-5'-methoxy-2-(3-(4-(2-morpholinoethyl)styryl)-1H-indazol-6-yl)spiro(cyclopropane-1,3'-indolin)-2'-one 2,2,2-trifluoroacetate

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine / bis(tri-t-butylphosphine)palladium⁽⁰⁾ / toluene / 2 h / 80 °C / Inert atmosphere; Microwave irradiation

2: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / ethanol; toluene / 2 h / 125 °C / Inert atmosphere; Microwave irradiation

3: water; acetonitrile

With sodium carbonate; triethylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; bis(tri-t-butylphosphine)palladium⁽⁰⁾; In ethanol; water; toluene; acetonitrile; 2: Suzuki Coupling;

Reference yield:

: (1R*,2S*)-2-(3-iodo-1H-indazol-6-yl)-5'-methoxyspiro[cyclopropane-1,3'-indolin]-2'-one

: 1338806-02-2
(1R,2S)-(E)-5'-methoxy-2-(3-(4-(2-morpholinoethyl)styryl)-1H-indazol-6-yl)spiro(cyclopropane-1,3'-indolin)-2'-one 2,2,2-trifluoroacetate

Guidance literature:: Multi-step reaction with 3 steps

1: carbon dioxide; diethylamine / methanol / Resolution of racemate

2: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / ethanol; toluene / 2 h / 125 °C / Inert atmosphere; Microwave irradiation

3: water; acetonitrile

With carbon dioxide; sodium carbonate; diethylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In methanol; ethanol; water; toluene; acetonitrile; 2: Suzuki Coupling;