(1R,2S)-(E)-5'-methoxy-2-(3-(4-(2-morpholinoethyl)styryl)-1H-indazol-6-yl)spiro(cyclopropane-1,3'-indolin)-2'-one

Base Information

Chemical Name:(1R,2S)-(E)-5'-methoxy-2-(3-(4-(2-morpholinoethyl)styryl)-1H-indazol-6-yl)spiro(cyclopropane-1,3'-indolin)-2'-one
CAS No.:1247002-61-4
Molecular Formula:C₃₂H₃₂N₄O₃
Molecular Weight:520.631
Hs Code.:

Synonyms:(1R,2S)-(E)-5'-methoxy-2-(3-(4-(2-morpholinoethyl)styryl)-1H-indazol-6-yl)spiro(cyclopropane-1,3'-indolin)-2'-one

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Chemical Property of (1R,2S)-(E)-5'-methoxy-2-(3-(4-(2-morpholinoethyl)styryl)-1H-indazol-6-yl)spiro(cyclopropane-1,3'-indolin)-2'-one

Chemical Property:

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Technology Process of (1R,2S)-(E)-5'-methoxy-2-(3-(4-(2-morpholinoethyl)styryl)-1H-indazol-6-yl)spiro(cyclopropane-1,3'-indolin)-2'-one

There total 4 articles about (1R,2S)-(E)-5'-methoxy-2-(3-(4-(2-morpholinoethyl)styryl)-1H-indazol-6-yl)spiro(cyclopropane-1,3'-indolin)-2'-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1247002-63-6
(E)-4-(4-(2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)vinyl)phenethyl)morpholine

: 1247001-86-0
(1R,2S)-2-(3-iodo-1H-indazol-6-yl)-5'-methoxyspiro[cyclopropane-1,3'-indolin]-2'-one

: 1247002-61-4
(1R,2S)-(E)-5'-methoxy-2-(3-(4-(2-morpholinoethyl)styryl)-1H-indazol-6-yl)spiro(cyclopropane-1,3'-indolin)-2'-one

Guidance literature:: With sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In ethanol; water; toluene; at 125 ℃; for 2h; Inert atmosphere; Microwave irradiation;

Reference yield:

: 736991-39-2
4-[2-(4-bromophenyl)ethyl]morpholine

: 1247002-61-4
(1R,2S)-(E)-5'-methoxy-2-(3-(4-(2-morpholinoethyl)styryl)-1H-indazol-6-yl)spiro(cyclopropane-1,3'-indolin)-2'-one

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / bis(tri-t-butylphosphine)palladium⁽⁰⁾ / toluene / 2 h / 80 °C / Inert atmosphere; Microwave irradiation

2: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / ethanol; toluene / 2 h / 125 °C / Inert atmosphere; Microwave irradiation

With sodium carbonate; triethylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; bis(tri-t-butylphosphine)palladium⁽⁰⁾; In ethanol; toluene; 2: Suzuki Coupling;

Reference yield:

: (1R*,2S*)-2-(3-iodo-1H-indazol-6-yl)-5'-methoxyspiro[cyclopropane-1,3'-indolin]-2'-one

: 1247002-61-4
(1R,2S)-(E)-5'-methoxy-2-(3-(4-(2-morpholinoethyl)styryl)-1H-indazol-6-yl)spiro(cyclopropane-1,3'-indolin)-2'-one

Guidance literature:: Multi-step reaction with 2 steps

1: carbon dioxide; diethylamine / methanol / Resolution of racemate

2: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / ethanol; toluene / 2 h / 125 °C / Inert atmosphere; Microwave irradiation

With carbon dioxide; sodium carbonate; diethylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In methanol; ethanol; toluene; 2: Suzuki Coupling;