(+/-)-3-benzyloxy-2,2-difluorotetradecanoic acid

Base Information

Chemical Name:(+/-)-3-benzyloxy-2,2-difluorotetradecanoic acid
CAS No.:177086-14-5
Molecular Formula:C₂₁H₃₂F₂O₃
Molecular Weight:370.48
Hs Code.:

Synonyms:(+/-)-3-benzyloxy-2,2-difluorotetradecanoic acid

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (+/-)-3-benzyloxy-2,2-difluorotetradecanoic acid

Chemical Property:

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Technology Process of (+/-)-3-benzyloxy-2,2-difluorotetradecanoic acid

There total 1 articles about (+/-)-3-benzyloxy-2,2-difluorotetradecanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: (+/-)-ethyl 3-benzyloxy-2,2-difluorotetradecanoate

: 177086-14-5
(+/-)-3-benzyloxy-2,2-difluorotetradecanoic acid

Guidance literature:: With potassium hydroxide; In ethanol; at 25 ℃; for 1h;
DOI:10.1246/bcsj.70.1149

Reference yield:

: 177086-14-5
(+/-)-3-benzyloxy-2,2-difluorotetradecanoic acid

: 177085-95-9
(+/-)-3-benzyloxy-2,2-difluorotetradecanoyl chloride

Guidance literature:: With oxalyl dichloride; In dichloromethane; at 24 ℃; for 1h;
DOI:10.1246/bcsj.70.1149

Reference yield:

: 177086-14-5
(+/-)-3-benzyloxy-2,2-difluorotetradecanoic acid

: 3-Benzyloxy-2,2-difluoro-tetradecanoic acid ((2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-hydroxymethyl-tetrahydro-pyran-2-yl)-amide

Guidance literature:: Multi-step reaction with 3 steps

1: oxalyl chloride / CH₂Cl₂ / 1 h / 24 °C

2: 94 percent / triethylamine / CH₂Cl₂ / 0.5 h / 0 - 25 °C

3: sodium methoxide / methanol / 0.5 h / 24 °C

With oxalyl dichloride; sodium methylate; triethylamine; In methanol; dichloromethane; 1: Chlorination / 2: Acylation / 3: Deacetylation;
DOI:10.1246/bcsj.70.1149