N-[3-benzyloxy-2,2-difluorotetradecanoyl]-2,3,4,6-tetra-O-acetyl-β-D-glucopyranosylamine

Base Information

Chemical Name:N-[3-benzyloxy-2,2-difluorotetradecanoyl]-2,3,4,6-tetra-O-acetyl-β-D-glucopyranosylamine
CAS No.:191157-41-2
Molecular Formula:C₃₅H₅₁F₂NO₁₁
Molecular Weight:699.787
Hs Code.:

Synonyms:N-[3-benzyloxy-2,2-difluorotetradecanoyl]-2,3,4,6-tetra-O-acetyl-β-D-glucopyranosylamine

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Chemical Property of N-[3-benzyloxy-2,2-difluorotetradecanoyl]-2,3,4,6-tetra-O-acetyl-β-D-glucopyranosylamine

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Technology Process of N-[3-benzyloxy-2,2-difluorotetradecanoyl]-2,3,4,6-tetra-O-acetyl-β-D-glucopyranosylamine

There total 4 articles about N-[3-benzyloxy-2,2-difluorotetradecanoyl]-2,3,4,6-tetra-O-acetyl-β-D-glucopyranosylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 41355-50-4,51642-81-0,58484-22-3,70128-27-7,70145-20-9,94482-21-0,98300-76-6
2,3,4,6-tetra-O-acetyl-D-glucosyl-1-amine

: 177085-95-9
(+/-)-3-benzyloxy-2,2-difluorotetradecanoyl chloride

: 191157-41-2
N-[3-benzyloxy-2,2-difluorotetradecanoyl]-2,3,4,6-tetra-O-acetyl-β-D-glucopyranosylamine

Guidance literature:: With triethylamine; In dichloromethane; at 0 - 25 ℃; for 0.5h;
DOI:10.1246/bcsj.70.1149

Reference yield:

: 100-39-0
benzyl bromide

: 191157-41-2
N-[3-benzyloxy-2,2-difluorotetradecanoyl]-2,3,4,6-tetra-O-acetyl-β-D-glucopyranosylamine

Guidance literature:: Multi-step reaction with 4 steps

1: 72 percent / NaH / dimethylformamide / 3 h / 25 °C

2: 87 percent / aq. KOH / ethanol / 1 h / 25 °C

3: oxalyl chloride / CH₂Cl₂ / 1 h / 24 °C

4: 94 percent / triethylamine / CH₂Cl₂ / 0.5 h / 0 - 25 °C

With potassium hydroxide; oxalyl dichloride; sodium hydride; triethylamine; In ethanol; dichloromethane; N,N-dimethyl-formamide; 1: Etherification / 2: Hydrolysis / 3: Chlorination / 4: Acylation;
DOI:10.1246/bcsj.70.1149

Reference yield:

: 177086-14-5
(+/-)-3-benzyloxy-2,2-difluorotetradecanoic acid

: 191157-41-2
N-[3-benzyloxy-2,2-difluorotetradecanoyl]-2,3,4,6-tetra-O-acetyl-β-D-glucopyranosylamine

Guidance literature:: Multi-step reaction with 2 steps

1: oxalyl chloride / CH₂Cl₂ / 1 h / 24 °C

2: 94 percent / triethylamine / CH₂Cl₂ / 0.5 h / 0 - 25 °C

With oxalyl dichloride; triethylamine; In dichloromethane; 1: Chlorination / 2: Acylation;
DOI:10.1246/bcsj.70.1149