3-[2-(4'-tert-butylbiphenyl-4-yloxy)acetylamino]benzoic acid methyl ester

Base Information

Chemical Name:3-[2-(4'-tert-butylbiphenyl-4-yloxy)acetylamino]benzoic acid methyl ester
CAS No.:1360869-74-4
Molecular Formula:C₂₆H₂₇NO₄
Molecular Weight:417.505
Hs Code.:

Synonyms:3-[2-(4'-tert-butylbiphenyl-4-yloxy)acetylamino]benzoic acid methyl ester

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Chemical Property of 3-[2-(4'-tert-butylbiphenyl-4-yloxy)acetylamino]benzoic acid methyl ester

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Technology Process of 3-[2-(4'-tert-butylbiphenyl-4-yloxy)acetylamino]benzoic acid methyl ester

There total 4 articles about 3-[2-(4'-tert-butylbiphenyl-4-yloxy)acetylamino]benzoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 15.0%

: 303794-33-4
3-[2-(4-bromophenoxy)acetylamino]benzoic acid methyl ester

: 123324-71-0
p-tert-butylphenylboronic acid

: 1360869-74-4
3-[2-(4'-tert-butylbiphenyl-4-yloxy)acetylamino]benzoic acid methyl ester

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium hydrogencarbonate; In ethanol; water; toluene; for 16h; Reflux; Inert atmosphere;
DOI:10.1016/j.bmc.2011.10.051

Reference yield:

: 1878-91-7
(4-bromophenoxy)acetic acid

: 1360869-74-4
3-[2-(4'-tert-butylbiphenyl-4-yloxy)acetylamino]benzoic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 48 h / 20 °C / Inert atmosphere

2: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium hydrogencarbonate / ethanol; water; toluene / 16 h / Reflux; Inert atmosphere

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium hydrogencarbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In ethanol; water; N,N-dimethyl-formamide; toluene;
DOI:10.1016/j.bmc.2011.10.051

Reference yield:

: 106-41-2
4-bromo-phenol

: 1360869-74-4
3-[2-(4'-tert-butylbiphenyl-4-yloxy)acetylamino]benzoic acid methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium carbonate / N,N-dimethyl-formamide / 20 °C / Inert atmosphere

2.1: lithium hydroxide monohydrate / tetrahydrofuran; water / 20 °C / Inert atmosphere

2.2: 20 °C / Inert atmosphere

3.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 48 h / 20 °C / Inert atmosphere

4.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium hydrogencarbonate / ethanol; water; toluene / 16 h / Reflux; Inert atmosphere

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; lithium hydroxide monohydrate; sodium hydrogencarbonate; sodium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; ethanol; water; N,N-dimethyl-formamide; toluene;
DOI:10.1016/j.bmc.2011.10.051