3-[2-(4'-tert-butylbiphenyl-4-yloxy)acetylamino]benzoic acid

Base Information

• Chemical Name: 3-[2-(4'-tert-butylbiphenyl-4-yloxy)acetylamino]benzoic acid
• CAS No.: 1360869-92-6
• Molecular Formula: C₂₅H₂₅NO₄
• Molecular Weight: 403.478
• Mol file: 1360869-92-6.mol

Synonyms:3-[2-(4'-tert-butylbiphenyl-4-yloxy)acetylamino]benzoic acid

Chemical Property of 3-[2-(4'-tert-butylbiphenyl-4-yloxy)acetylamino]benzoic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-[2-(4'-tert-butylbiphenyl-4-yloxy)acetylamino]benzoic acid

There total 5 articles about 3-[2-(4'-tert-butylbiphenyl-4-yloxy)acetylamino]benzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 25.0%

3-[2-(4'-tert-butylbiphenyl-4-yloxy)acetylamino]benzoic acid methyl ester (1360869-74-4) → 3-[2-(4'-tert-butylbiphenyl-4-yloxy)acetylamino]benzoic acid (1360869-92-6)

Guidance literature:

3-[2-(4'-tert-butylbiphenyl-4-yloxy)acetylamino]benzoic acid methyl ester; With lithium hydroxide monohydrate; In tetrahydrofuran; water; at 20 ℃; for 24h; Inert atmosphere;

With hydrogenchloride; In tetrahydrofuran; water; at 20 ℃; Inert atmosphere;

DOI:10.1016/j.bmc.2011.10.051

Reference yield:

3-[2-(4-bromophenoxy)acetylamino]benzoic acid methyl ester (303794-33-4) → 3-[2-(4'-tert-butylbiphenyl-4-yloxy)acetylamino]benzoic acid (1360869-92-6)

Guidance literature:

Multi-step reaction with 2 steps

1.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium hydrogencarbonate / ethanol; water; toluene / 16 h / Reflux; Inert atmosphere

2.1: lithium hydroxide monohydrate / tetrahydrofuran; water / 24 h / 20 °C / Inert atmosphere

2.2: 20 °C / Inert atmosphere

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; lithium hydroxide monohydrate; sodium hydrogencarbonate; In tetrahydrofuran; ethanol; water; toluene;

DOI:10.1016/j.bmc.2011.10.051

Reference yield:

(4-bromophenoxy)acetic acid (1878-91-7) → 3-[2-(4'-tert-butylbiphenyl-4-yloxy)acetylamino]benzoic acid (1360869-92-6)

Guidance literature:

Multi-step reaction with 3 steps

1.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 48 h / 20 °C / Inert atmosphere

2.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium hydrogencarbonate / ethanol; water; toluene / 16 h / Reflux; Inert atmosphere

3.1: lithium hydroxide monohydrate / tetrahydrofuran; water / 24 h / 20 °C / Inert atmosphere

3.2: 20 °C / Inert atmosphere

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; lithium hydroxide monohydrate; sodium hydrogencarbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; ethanol; water; N,N-dimethyl-formamide; toluene;

DOI:10.1016/j.bmc.2011.10.051

upstream raw materials:

3-[2-(4-bromophenoxy)acetylamino]benzoic acid methyl ester

(4-bromophenoxy)acetic acid

3-[2-(4'-tert-butylbiphenyl-4-yloxy)acetylamino]benzoic acid methyl ester

4-bromo-phenol