8-chloro-1-methyl-6-phenyl-4H-<1,2,4>triazolo<4,3-a><1,5>benzodiazepine-5(6H)-thione

Base Information

Chemical Name:8-chloro-1-methyl-6-phenyl-4H-<1,2,4>triazolo<4,3-a><1,5>benzodiazepine-5(6H)-thione
CAS No.:153901-41-8
Molecular Formula:C₁₇H₁₃ClN₄S
Molecular Weight:340.836
Hs Code.:

Synonyms:8-chloro-1-methyl-6-phenyl-4H-<1,2,4>triazolo<4,3-a><1,5>benzodiazepine-5(6H)-thione

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Chemical Property of 8-chloro-1-methyl-6-phenyl-4H-<1,2,4>triazolo<4,3-a><1,5>benzodiazepine-5(6H)-thione

Chemical Property:

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MSDS Files:: SDS file from LookChem

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Technology Process of 8-chloro-1-methyl-6-phenyl-4H-<1,2,4>triazolo<4,3-a><1,5>benzodiazepine-5(6H)-thione

There total 3 articles about 8-chloro-1-methyl-6-phenyl-4H-<1,2,4>triazolo<4,3-a><1,5>benzodiazepine-5(6H)-thione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 54748-06-0
8-chloro-1-methyl-6-phenyl-4H-<1,2,4>triazolo<4,3-a><1,5>benzodiazepin-5(6H)-one

: 153901-41-8
8-chloro-1-methyl-6-phenyl-4H-<1,2,4>triazolo<4,3-a><1,5>benzodiazepine-5(6H)-thione

Guidance literature:: With Lawessons reagent; In various solvent(s); at 150 ℃; for 0.5h;
DOI:10.1016/0223-5234(93)90088-V

Reference yield:

: 22316-55-8
N-desmethylclobazam

: 153901-41-8
8-chloro-1-methyl-6-phenyl-4H-<1,2,4>triazolo<4,3-a><1,5>benzodiazepine-5(6H)-thione

Guidance literature:: Multi-step reaction with 3 steps

1: 70 percent / TiCl₄, anisole / toluene / 6 h / Heating

2: 80 percent / gl. AcOH / various solvent(s) / 2 h / 200 °C

3: 78 percent / Lawesson's reagent / various solvent(s) / 0.5 h / 150 °C

With Lawessons reagent; titanium tetrachloride; acetic acid; methoxybenzene; In toluene;
DOI:10.1016/0223-5234(93)90088-V

Reference yield:

: 36985-45-2
8-chloro-4-(dimethylamino)-1,3-dihydro-1-phenyl-2H-1,5-benzodiazepin-2-one

: 153901-41-8
8-chloro-1-methyl-6-phenyl-4H-<1,2,4>triazolo<4,3-a><1,5>benzodiazepine-5(6H)-thione

Guidance literature:: Multi-step reaction with 2 steps

1: 80 percent / gl. AcOH / various solvent(s) / 2 h / 200 °C

2: 78 percent / Lawesson's reagent / various solvent(s) / 0.5 h / 150 °C

With Lawessons reagent; acetic acid; In various solvent(s);
DOI:10.1016/0223-5234(93)90088-V