4-[2-(2,5-dimethyl-4-{[(E)-(methylamino)methylidene]amino}benzyl)-1,3-thiazol-4-yl]-N-methylbenzamide

Base Information

Chemical Name:4-[2-(2,5-dimethyl-4-{[(E)-(methylamino)methylidene]amino}benzyl)-1,3-thiazol-4-yl]-N-methylbenzamide
CAS No.:1421932-36-6
Molecular Formula:C₂₂H₂₄N₄OS
Molecular Weight:392.525
Hs Code.:

Synonyms:4-[2-(2,5-dimethyl-4-{[(E)-(methylamino)methylidene]amino}benzyl)-1,3-thiazol-4-yl]-N-methylbenzamide

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Chemical Property of 4-[2-(2,5-dimethyl-4-{[(E)-(methylamino)methylidene]amino}benzyl)-1,3-thiazol-4-yl]-N-methylbenzamide

Chemical Property:

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Technology Process of 4-[2-(2,5-dimethyl-4-{[(E)-(methylamino)methylidene]amino}benzyl)-1,3-thiazol-4-yl]-N-methylbenzamide

There total 7 articles about 4-[2-(2,5-dimethyl-4-{[(E)-(methylamino)methylidene]amino}benzyl)-1,3-thiazol-4-yl]-N-methylbenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 123-39-7
N-Methylformamide

: 1421923-11-6
4-[2-(4-amino-2,5-dimethylbenzyl)-1,3-thiazol-4-yl]-N-methylbenzamide

: 1421932-36-6
4-[2-(2,5-dimethyl-4-{[(E)-(methylamino)methylidene]amino}benzyl)-1,3-thiazol-4-yl]-N-methylbenzamide

Guidance literature:: With p-toluenesulfonyl chloride; at 20 ℃; for 3h;

Reference yield:

: 1421922-32-8
4-[2-(2,5-dimethyl-4-nitrobenzyl)-1,3-thiazol-4-yl]benzoic acid

: 1421932-36-6
4-[2-(2,5-dimethyl-4-{[(E)-(methylamino)methylidene]amino}benzyl)-1,3-thiazol-4-yl]-N-methylbenzamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.08 h

1.2: 0.5 h / 20 °C

2.1: water; palladium(II) hydroxide / ethanol / 16 h / 20 °C

3.1: p-toluenesulfonyl chloride / 3 h / 20 °C

With water; palladium(II) hydroxide; N-ethyl-N,N-diisopropylamine; p-toluenesulfonyl chloride; In ethanol; N,N-dimethyl-formamide;

Reference yield:

: 1421922-04-4
2-(2,5-dimethyl-4-nitrophenyl)ethanethioamide

: 1421932-36-6
4-[2-(2,5-dimethyl-4-{[(E)-(methylamino)methylidene]amino}benzyl)-1,3-thiazol-4-yl]-N-methylbenzamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: isopropyl alcohol / 2 h / 80 °C

2.1: sodium hydroxide; water / methanol / 2 h / 50 °C

3.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.08 h

3.2: 0.5 h / 20 °C

4.1: water; palladium(II) hydroxide / ethanol / 16 h / 20 °C

5.1: p-toluenesulfonyl chloride / 3 h / 20 °C

With water; palladium(II) hydroxide; N-ethyl-N,N-diisopropylamine; p-toluenesulfonyl chloride; sodium hydroxide; In methanol; ethanol; N,N-dimethyl-formamide; isopropyl alcohol;