5-Acetyl-4-(4-dimethylamino-phenyl)-6-methyl-2-methylsulfanyl-nicotinonitrile

Base Information

Chemical Name:5-Acetyl-4-(4-dimethylamino-phenyl)-6-methyl-2-methylsulfanyl-nicotinonitrile
CAS No.:121104-42-5
Molecular Formula:C₁₈H₁₉N₃OS
Molecular Weight:325.434
Hs Code.:

Synonyms:5-Acetyl-4-(4-dimethylamino-phenyl)-6-methyl-2-methylsulfanyl-nicotinonitrile

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Chemical Property of 5-Acetyl-4-(4-dimethylamino-phenyl)-6-methyl-2-methylsulfanyl-nicotinonitrile

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Technology Process of 5-Acetyl-4-(4-dimethylamino-phenyl)-6-methyl-2-methylsulfanyl-nicotinonitrile

There total 5 articles about 5-Acetyl-4-(4-dimethylamino-phenyl)-6-methyl-2-methylsulfanyl-nicotinonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 121104-39-0
5-Acetyl-4-(4-dimethylamino-phenyl)-6-methyl-2-thioxo-1,2-dihydro-pyridine-3-carbonitrile

: 74-88-4
methyl iodide

: 121104-42-5
5-Acetyl-4-(4-dimethylamino-phenyl)-6-methyl-2-methylsulfanyl-nicotinonitrile

Guidance literature:: With potassium hydroxide; In dichloromethane; for 3h; Ambient temperature;
DOI:10.1246/bcsj.61.4431

Reference yield:

: 68029-58-3,37401-21-1
2-cyano-3-(4-(dimethylamino)phenyl)prop-2-enethioamide

: 121104-42-5
5-Acetyl-4-(4-dimethylamino-phenyl)-6-methyl-2-methylsulfanyl-nicotinonitrile

Guidance literature:: Multi-step reaction with 2 steps

1: Et₃N / methanol / 6 h / Heating

2: NaOMe / methanol / 0.75 h / Heating

With sodium methylate; triethylamine; In methanol; 1: Condensation / 2: Methylation;
DOI:10.1080/10426509908037010

Reference yield:

: 123-54-6,81235-32-7
acetylacetone

: 121104-42-5
5-Acetyl-4-(4-dimethylamino-phenyl)-6-methyl-2-methylsulfanyl-nicotinonitrile

Guidance literature:: Multi-step reaction with 2 steps

1: 80 percent / piperidine / ethanol / 3 h / Heating

2: 75 percent / KOH / CH₂Cl₂ / 3 h / Ambient temperature

With piperidine; potassium hydroxide; In ethanol; dichloromethane;
DOI:10.1246/bcsj.61.4431