4-(N-methyl-N-(2-hydroxyethyl)amino)-2-N-ethylamino-1-(3-(5-iodothiophen-2-yl)acrylamido)benzene

Base Information

Chemical Name:4-(N-methyl-N-(2-hydroxyethyl)amino)-2-N-ethylamino-1-(3-(5-iodothiophen-2-yl)acrylamido)benzene
CAS No.:1363336-65-5
Molecular Formula:C₁₈H₂₂IN₃O₂S
Molecular Weight:471.362
Hs Code.:

Synonyms:4-(N-methyl-N-(2-hydroxyethyl)amino)-2-N-ethylamino-1-(3-(5-iodothiophen-2-yl)acrylamido)benzene

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Chemical Property of 4-(N-methyl-N-(2-hydroxyethyl)amino)-2-N-ethylamino-1-(3-(5-iodothiophen-2-yl)acrylamido)benzene

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Technology Process of 4-(N-methyl-N-(2-hydroxyethyl)amino)-2-N-ethylamino-1-(3-(5-iodothiophen-2-yl)acrylamido)benzene

There total 7 articles about 4-(N-methyl-N-(2-hydroxyethyl)amino)-2-N-ethylamino-1-(3-(5-iodothiophen-2-yl)acrylamido)benzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1363336-67-7
(E)-3-(5-iodothiophen-2-yl)acryloyl chloride

: C₁₁H₁₉N₃O

: 1363336-65-5
4-(N-methyl-N-(2-hydroxyethyl)amino)-2-N-ethylamino-1-(3-(5-iodothiophen-2-yl)acrylamido)benzene

Guidance literature:: With triethylamine; In tetrahydrofuran; at 20 ℃; for 2h; Inert atmosphere;
DOI:10.1016/j.tetlet.2012.01.023

Reference yield:

: 5370-19-4
5-iodothiophene-2-carbaldehyde

: 1363336-65-5
4-(N-methyl-N-(2-hydroxyethyl)amino)-2-N-ethylamino-1-(3-(5-iodothiophen-2-yl)acrylamido)benzene

Guidance literature:: Multi-step reaction with 3 steps

1: piperidine; pyridine / 10 h / 75 °C

2: thionyl chloride / 2 h / Reflux

3: triethylamine / tetrahydrofuran / 2 h / 20 °C / Inert atmosphere

With piperidine; pyridine; thionyl chloride; triethylamine; In tetrahydrofuran; 1: Perkin reaction;
DOI:10.1016/j.tetlet.2012.01.023

Reference yield:

: 1363336-68-8
(E)-3-(5-iodothiophen-2-yl)acrylic acid

: 1363336-65-5
4-(N-methyl-N-(2-hydroxyethyl)amino)-2-N-ethylamino-1-(3-(5-iodothiophen-2-yl)acrylamido)benzene

Guidance literature:: Multi-step reaction with 2 steps

1: thionyl chloride / 2 h / Reflux

2: triethylamine / tetrahydrofuran / 2 h / 20 °C / Inert atmosphere

With thionyl chloride; triethylamine; In tetrahydrofuran;
DOI:10.1016/j.tetlet.2012.01.023