5370-19-4

Basic information

• Product Name: 5 - Iodothiophene - 2 - carbaldehyde
• Synonyms: 2-Thiophenecarboxaldehyde, 5-iodo-; 5-Iodo-2-thiophenecarboxaldehyde
• CAS NO: 5370-19-4
• Molecular Formula: C₅H₃IOS
• Molecular Weight: 238.04619
• Mol File: 5370-19-4.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 283.6°Cat760mmHg
• Flash Point: 125.3°C
• Appearance: /
• Density: 2.113g/cm³
• Vapor Pressure: 0.00313mmHg at 25°C
• Refractive Index: 1.715
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 5 - Iodothiophene - 2 - carbaldehyde(CAS DataBase Reference)
• NIST Chemistry Reference: 5 - Iodothiophene - 2 - carbaldehyde(5370-19-4)
• EPA Substance Registry System: 5 - Iodothiophene - 2 - carbaldehyde(5370-19-4)

Safety Data

• Hazardous Substances Data: 5370-19-4(Hazardous Substances Data)

Usage

General Description

5-Iodothiophene-2-carbaldehyde is a chemical compound with the molecular formula C6H4IO. It is a derivative of thiophene, a heterocyclic compound containing a five-membered ring of four carbon atoms and one sulfur atom. The presence of the iodine and aldehyde functional groups in this compound make it useful in a variety of organic synthesis reactions. It is commonly used as a building block in the synthesis of pharmaceuticals, agrochemicals, and materials for electronic applications. Additionally, 5-Iodothiophene-2-carbaldehyde has exhibited potential biological activity, and its derivatives have been investigated for their antiviral, antibacterial, and anti-inflammatory properties.

InChI:InChI=1/C5H3IOS/c6-5-2-1-4(3-7)8-5/h1-3H

Upstream product

• 636-72-6 2-thiophenemethanol 
• 3437-95-4 2-Iodothiophene 
• 68-12-2 N,N-dimethyl-formamide 
• 98-03-3 thiophene-2-carbaldehyde 

Downstream Products

• 17257-10-2 5-(phenylethynyl)thiophene-2-carboxaldehyde 
• 1280722-20-4 ethyl 4-(5-((1-hydroxycyclohexyl)ethynyl)thiophen-2-yl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate 
• 32358-94-4 5-methyl-2,2'-bithiophene-5'-carboxaldehyde 
• 3779-27-9 2,2'-bithiophene-5-carboxaldehyde 
• 1363336-65-5 4-(N-methyl-N-(2-hydroxyethyl)amino)-2-N-ethylamino-1-(3-(5-iodothiophen-2-yl)acrylamido)benzene 
• 1665-35-6 5-ethynyl-2-phenylthiophene 
• 1134-61-8 5-but-3-en-1-ynyl-[2,2']bithiophenyl 
• 1204-82-6 2-Phenyl-5-(1'-propynyl)-thiophene 
• 72157-21-2 (5-formyl-2-thienyl)phenylmethanone 
• 19163-21-4 5-phenylthiophene-2-carboxaldehyde 
• 1562410-54-1 C₂₉H₂₀BF₂IN₂S 

Relevant articles and documents

METHOD FOR PRODUCING CARBONYL COMPOUND

PROBLEM TO BE SOLVED: To provide a method for producing a carbonyl compound, allowing for improvement of ease of production and furthermore allowing for reduction of production cost, by positively utilizing inexpensive iodine. SOLUTION: A carbonyl compound is produced by mixing primary alcohol or secondary alcohol, and iodic acid (HIO3) in a non-solvent or an aprotic polar solvent based on the following general formula (1), where R1 is an optionally substituted linear- or branched 1-12C aliphatic group, or an optionally substituted aromatic group; R2 is a hydrogen atom, an optionally substituted linear- or branched 1-12C alkyl group, or an optionally substituted aromatic group; R1 and R2 each may be coupled with each other to form a ring of aromatic group or a non-aromatic group. SELECTED DRAWING: None COPYRIGHT: (C)2018,JPOandINPIT

Chemistry of polyhalogenated nitrobutadienes, part 11: Ipso-formylation of 2-chlorothiophenes under Vilsmeier-Haack conditions

The regioselective ipso-formylation of electron-rich, 3,4-push-pull- substituted 2-chlorothiophenes under Vilsmeier-Haack conditions was performed in good yields. The synthetic scope of this new reaction was explored using various halothiophenes, chloroanilines, and 1-methyl-3-chloroindole. In comparison with their structural C-H analogs the chlorinated thiophenes, anilines, and the indole proved to be less reactive toward electrophilic attack by chloromethyleniminium salts.