Dithiophosphoric acid O-[(2R,3R,4R,5R)-2-hydroxymethyl-5-(6-{[(4-methoxy-phenyl)-diphenyl-methyl]-amino}-purin-9-yl)-4-(tetrahydro-pyran-2-yloxy)-tetrahydro-furan-3-yl] ester S,S'-diphenyl ester

Base Information

Chemical Name:Dithiophosphoric acid O-[(2R,3R,4R,5R)-2-hydroxymethyl-5-(6-{[(4-methoxy-phenyl)-diphenyl-methyl]-amino}-purin-9-yl)-4-(tetrahydro-pyran-2-yloxy)-tetrahydro-furan-3-yl] ester S,S'-diphenyl ester
CAS No.:81244-14-6
Molecular Formula:C₄₇H₄₆N₅O₇PS₂
Molecular Weight:888.017
Hs Code.:

Dithiophosphoric acid O-[(2R,3R,4R,5R)-2-hydroxymethyl-5-(6-{[(4-methoxy-phenyl)-diphenyl-methyl]-amino}-purin-9-yl)-4-(tetrahydro-pyran-2-yloxy)-tetrahydro-furan-3-yl] ester S,S'-diphenyl ester

Synonyms:Dithiophosphoric acid O-[(2R,3R,4R,5R)-2-hydroxymethyl-5-(6-{[(4-methoxy-phenyl)-diphenyl-methyl]-amino}-purin-9-yl)-4-(tetrahydro-pyran-2-yloxy)-tetrahydro-furan-3-yl] ester S,S'-diphenyl ester

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Chemical Property of Dithiophosphoric acid O-[(2R,3R,4R,5R)-2-hydroxymethyl-5-(6-{[(4-methoxy-phenyl)-diphenyl-methyl]-amino}-purin-9-yl)-4-(tetrahydro-pyran-2-yloxy)-tetrahydro-furan-3-yl] ester S,S'-diphenyl ester

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Technology Process of Dithiophosphoric acid O-[(2R,3R,4R,5R)-2-hydroxymethyl-5-(6-{[(4-methoxy-phenyl)-diphenyl-methyl]-amino}-purin-9-yl)-4-(tetrahydro-pyran-2-yloxy)-tetrahydro-furan-3-yl] ester S,S'-diphenyl ester

There total 10 articles about Dithiophosphoric acid O-[(2R,3R,4R,5R)-2-hydroxymethyl-5-(6-{[(4-methoxy-phenyl)-diphenyl-methyl]-amino}-purin-9-yl)-4-(tetrahydro-pyran-2-yloxy)-tetrahydro-furan-3-yl] ester S,S'-diphenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 102633-24-9
C₉₀H₆₃Cl₆N₈O₁₃PS₂

: 81244-14-6
Dithiophosphoric acid O-[(2R,3R,4R,5R)-2-hydroxymethyl-5-(6-{[(4-methoxy-phenyl)-diphenyl-methyl]-amino}-purin-9-yl)-4-(tetrahydro-pyran-2-yloxy)-tetrahydro-furan-3-yl] ester S,S'-diphenyl ester

Guidance literature:: With hydrazine hydrate; In pyridine; acetic acid; for 0.333333h; Ambient temperature;
DOI:10.1021/ja00275a052

Reference yield: 92.0%

: 81244-08-8
Dithiophosphoric acid O-[(2R,3R,4R,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(6-{[(4-methoxy-phenyl)-diphenyl-methyl]-amino}-purin-9-yl)-4-(tetrahydro-pyran-2-yloxy)-tetrahydro-furan-3-yl] ester S,S'-diphenyl ester

: 81244-14-6
Dithiophosphoric acid O-[(2R,3R,4R,5R)-2-hydroxymethyl-5-(6-{[(4-methoxy-phenyl)-diphenyl-methyl]-amino}-purin-9-yl)-4-(tetrahydro-pyran-2-yloxy)-tetrahydro-furan-3-yl] ester S,S'-diphenyl ester

Guidance literature:: With trifluoroacetic acid; In chloroform; at 0 ℃; for 0.833333h;
DOI:10.1016/0040-4020(84)85114-5

Reference yield:

: 69304-45-6
3',5'-O-(1,1,3,3-tetra-isopropyldisiloxane-1,3-diyl)adenosine

: 81244-14-6
Dithiophosphoric acid O-[(2R,3R,4R,5R)-2-hydroxymethyl-5-(6-{[(4-methoxy-phenyl)-diphenyl-methyl]-amino}-purin-9-yl)-4-(tetrahydro-pyran-2-yloxy)-tetrahydro-furan-3-yl] ester S,S'-diphenyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 96 percent / triethylamine / 4-(dimethylamino)pyridine / CH₂Cl₂ / 1 h / Ambient temperature

2: 84 percent / tetraethylammonium chloride; KF / acetonitrile; H₂O / 20 h / Ambient temperature

3: 89 percent

4: 86 percent / 2,4-dimethoxy-benzene-1,5-disulfonyl chloride(DMS); pyridine / 2 h

5: TsOH (2percent) / CH₂Cl₂; methanol / 0 °C

With pyridine; potassium fluoride; 4,6-dimethoxybenzene-1,3-bis(sulfonyl) chloride; tetraethylammonium chloride; toluene-4-sulfonic acid; triethylamine; dmap; In methanol; dichloromethane; water; acetonitrile;
DOI:10.1246/cl.1982.15