(+)-(R)-2-((R)-2-((4-methoxybenzyl)oxy)but-3-en-1-yl)-1,4-dioxaspiro[4.5]decane

Base Information

Chemical Name:(+)-(R)-2-((R)-2-((4-methoxybenzyl)oxy)but-3-en-1-yl)-1,4-dioxaspiro[4.5]decane
CAS No.:1440508-07-5
Molecular Formula:C₂₀H₂₈O₄
Molecular Weight:332.44
Hs Code.:

Synonyms:(+)-(R)-2-((R)-2-((4-methoxybenzyl)oxy)but-3-en-1-yl)-1,4-dioxaspiro[4.5]decane

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Chemical Property of (+)-(R)-2-((R)-2-((4-methoxybenzyl)oxy)but-3-en-1-yl)-1,4-dioxaspiro[4.5]decane

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Technology Process of (+)-(R)-2-((R)-2-((4-methoxybenzyl)oxy)but-3-en-1-yl)-1,4-dioxaspiro[4.5]decane

There total 5 articles about (+)-(R)-2-((R)-2-((4-methoxybenzyl)oxy)but-3-en-1-yl)-1,4-dioxaspiro[4.5]decane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 1440508-22-4
(-)-(R)-1-((R)-1,4-dioxaspiro[4.5]decan-2-yl)but-3-en-2-ol

: 824-94-2
p-methoxybenzyl chloride

: 1440508-07-5
(+)-(R)-2-((R)-2-((4-methoxybenzyl)oxy)but-3-en-1-yl)-1,4-dioxaspiro[4.5]decane

Guidance literature:: (-)-(R)-1-((R)-1,4-dioxaspiro[4.5]decan-2-yl)but-3-en-2-ol; With sodium hydride; N,N-dimethyl-formamide; at 0 ℃; Inert atmosphere;

p-methoxybenzyl chloride; With potassium iodide; at 20 ℃; Inert atmosphere;
DOI:10.1021/ja402891m

Reference yield:

: 10353-53-4
1,2-epoxy-5-hexene

: 1440508-07-5
(+)-(R)-2-((R)-2-((4-methoxybenzyl)oxy)but-3-en-1-yl)-1,4-dioxaspiro[4.5]decane

Guidance literature:: Multi-step reaction with 4 steps

1.1: C₂₀H₂₀CoN₂O₂⁽²⁺⁾ / water

2.1: toluene-4-sulfonic acid; 4-nitro-benzoic acid / benzene / 20 °C / Inert atmosphere

3.1: [1,2-bis-(phenylsulfinyl)ethane]palladium(II) acetate; p-benzoquinone; 4-nitro-benzoic acid; oxygen / 1,4-dioxane / 48 h / 45 °C

4.1: N,N-dimethyl-formamide; sodium hydride / 0 °C / Inert atmosphere

4.2: 20 °C / Inert atmosphere

With [1,2-bis-(phenylsulfinyl)ethane]palladium(II) acetate; C₂₀H₂₀CoN₂O₂⁽²⁺⁾; oxygen; sodium hydride; toluene-4-sulfonic acid; N,N-dimethyl-formamide; p-benzoquinone; 4-nitro-benzoic acid; In 1,4-dioxane; water; benzene;
DOI:10.1021/ja402891m

Reference yield:

: 133494-68-5
(R)-1,2-dihydroxy-5-hexene

: 1440508-07-5
(+)-(R)-2-((R)-2-((4-methoxybenzyl)oxy)but-3-en-1-yl)-1,4-dioxaspiro[4.5]decane

Guidance literature:: Multi-step reaction with 3 steps

1.1: toluene-4-sulfonic acid; 4-nitro-benzoic acid / benzene / 20 °C / Inert atmosphere

2.1: [1,2-bis-(phenylsulfinyl)ethane]palladium(II) acetate; p-benzoquinone; 4-nitro-benzoic acid; oxygen / 1,4-dioxane / 48 h / 45 °C

3.1: N,N-dimethyl-formamide; sodium hydride / 0 °C / Inert atmosphere

3.2: 20 °C / Inert atmosphere

With [1,2-bis-(phenylsulfinyl)ethane]palladium(II) acetate; oxygen; sodium hydride; toluene-4-sulfonic acid; N,N-dimethyl-formamide; p-benzoquinone; 4-nitro-benzoic acid; In 1,4-dioxane; benzene;
DOI:10.1021/ja402891m