2-((R)-1-((S)-2-(4-(5-(1-(4-fluorophenyl)-3-(trifluoromethyl)-1H-pyrazol-4-yl)-1,2,4-oxadiazol-3-yl)phenyl)-2-hydroxyethyl)piperidin-3-yl)acetic acid

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Chemical Name:2-((R)-1-((S)-2-(4-(5-(1-(4-fluorophenyl)-3-(trifluoromethyl)-1H-pyrazol-4-yl)-1,2,4-oxadiazol-3-yl)phenyl)-2-hydroxyethyl)piperidin-3-yl)acetic acid
CAS No.:1265323-36-1
Molecular Formula:C₂₇H₂₅F₄N₅O₄
Molecular Weight:559.52
Hs Code.:

Synonyms:2-((R)-1-((S)-2-(4-(5-(1-(4-fluorophenyl)-3-(trifluoromethyl)-1H-pyrazol-4-yl)-1,2,4-oxadiazol-3-yl)phenyl)-2-hydroxyethyl)piperidin-3-yl)acetic acid

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Chemical Property of 2-((R)-1-((S)-2-(4-(5-(1-(4-fluorophenyl)-3-(trifluoromethyl)-1H-pyrazol-4-yl)-1,2,4-oxadiazol-3-yl)phenyl)-2-hydroxyethyl)piperidin-3-yl)acetic acid

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Technology Process of 2-((R)-1-((S)-2-(4-(5-(1-(4-fluorophenyl)-3-(trifluoromethyl)-1H-pyrazol-4-yl)-1,2,4-oxadiazol-3-yl)phenyl)-2-hydroxyethyl)piperidin-3-yl)acetic acid

There total 14 articles about 2-((R)-1-((S)-2-(4-(5-(1-(4-fluorophenyl)-3-(trifluoromethyl)-1H-pyrazol-4-yl)-1,2,4-oxadiazol-3-yl)phenyl)-2-hydroxyethyl)piperidin-3-yl)acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₃₅H₄₃F₄N₅O₄Si

: 1265323-36-1
2-((R)-1-((S)-2-(4-(5-(1-(4-fluorophenyl)-3-(trifluoromethyl)-1H-pyrazol-4-yl)-1,2,4-oxadiazol-3-yl)phenyl)-2-hydroxyethyl)piperidin-3-yl)acetic acid

Guidance literature:: With hydrogenchloride; water; In 1,4-dioxane; at 80 ℃;

Reference yield:

: 352-34-1
4-fluoro-1-iodobenzene

: 1265323-36-1
2-((R)-1-((S)-2-(4-(5-(1-(4-fluorophenyl)-3-(trifluoromethyl)-1H-pyrazol-4-yl)-1,2,4-oxadiazol-3-yl)phenyl)-2-hydroxyethyl)piperidin-3-yl)acetic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium carbonate; (R,R)-N,N'-dimethyl-1,2-diaminocyclohexane / copper(l) iodide / toluene / Reflux

2.1: sodium hydroxide; water / ethanol

3.1: oxalyl dichloride / dichloromethane / 1 h / 20 °C

4.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran

4.2: Reflux

5.1: hydrogenchloride; water / 1,4-dioxane / 80 °C

With hydrogenchloride; oxalyl dichloride; (R,R)-N,N'-dimethyl-1,2-diaminocyclohexane; water; potassium carbonate; N-ethyl-N,N-diisopropylamine; sodium hydroxide; copper(l) iodide; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; toluene;

Reference yield:

: 155377-19-8
ethyl 3-trifluoromethyl-1H-pyrazole-4-carboxylate

: 1265323-36-1
2-((R)-1-((S)-2-(4-(5-(1-(4-fluorophenyl)-3-(trifluoromethyl)-1H-pyrazol-4-yl)-1,2,4-oxadiazol-3-yl)phenyl)-2-hydroxyethyl)piperidin-3-yl)acetic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium carbonate; (R,R)-N,N'-dimethyl-1,2-diaminocyclohexane / copper(l) iodide / toluene / Reflux

2.1: sodium hydroxide; water / ethanol

3.1: oxalyl dichloride / dichloromethane / 1 h / 20 °C

4.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran

4.2: Reflux

5.1: hydrogenchloride; water / 1,4-dioxane / 80 °C

With hydrogenchloride; oxalyl dichloride; (R,R)-N,N'-dimethyl-1,2-diaminocyclohexane; water; potassium carbonate; N-ethyl-N,N-diisopropylamine; sodium hydroxide; copper(l) iodide; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; toluene;