(3R,4S,5R)-2-Benzyl-3-[(2S,3R)-3-methoxy-1-(4-methoxy-phenyl)-4-oxo-azetidin-2-yl]-isoxazolidine-4,5-dicarboxylic acid dimethyl ester

Base Information

Chemical Name:(3R,4S,5R)-2-Benzyl-3-[(2S,3R)-3-methoxy-1-(4-methoxy-phenyl)-4-oxo-azetidin-2-yl]-isoxazolidine-4,5-dicarboxylic acid dimethyl ester
CAS No.:474086-11-8
Molecular Formula:C₂₅H₂₈N₂O₈
Molecular Weight:484.506
Hs Code.:

Synonyms:(3R,4S,5R)-2-Benzyl-3-[(2S,3R)-3-methoxy-1-(4-methoxy-phenyl)-4-oxo-azetidin-2-yl]-isoxazolidine-4,5-dicarboxylic acid dimethyl ester

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Chemical Property of (3R,4S,5R)-2-Benzyl-3-[(2S,3R)-3-methoxy-1-(4-methoxy-phenyl)-4-oxo-azetidin-2-yl]-isoxazolidine-4,5-dicarboxylic acid dimethyl ester

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Technology Process of (3R,4S,5R)-2-Benzyl-3-[(2S,3R)-3-methoxy-1-(4-methoxy-phenyl)-4-oxo-azetidin-2-yl]-isoxazolidine-4,5-dicarboxylic acid dimethyl ester

There total 3 articles about (3R,4S,5R)-2-Benzyl-3-[(2S,3R)-3-methoxy-1-(4-methoxy-phenyl)-4-oxo-azetidin-2-yl]-isoxazolidine-4,5-dicarboxylic acid dimethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 624-48-6
dimethyl cis-but-2-ene-1,4-dioate

: 474086-03-8
C₁₉H₂₀N₂O₄

: 474086-11-8
(3R,4S,5R)-2-Benzyl-3-[(2S,3R)-3-methoxy-1-(4-methoxy-phenyl)-4-oxo-azetidin-2-yl]-isoxazolidine-4,5-dicarboxylic acid dimethyl ester

Guidance literature:: In toluene; at 110 ℃;
DOI:10.1021/jo025924e

Reference yield:

: 29601-98-7
N-benzylhydroxylamine hydrochloride

: 474086-11-8
(3R,4S,5R)-2-Benzyl-3-[(2S,3R)-3-methoxy-1-(4-methoxy-phenyl)-4-oxo-azetidin-2-yl]-isoxazolidine-4,5-dicarboxylic acid dimethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 86 percent / Et₃N / benzene / 16 h / 20 °C

2: 95 percent / toluene / 110 °C

With triethylamine; In toluene; benzene; 2: Diels-Alder cycloaddition;
DOI:10.1021/jo025924e

Reference yield:

: 180062-99-1
3-methoxy-1-(4-methoxy-phenyl)-4-oxo-azetidine-2-carbaldehyde

: 474086-11-8
(3R,4S,5R)-2-Benzyl-3-[(2S,3R)-3-methoxy-1-(4-methoxy-phenyl)-4-oxo-azetidin-2-yl]-isoxazolidine-4,5-dicarboxylic acid dimethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 86 percent / Et₃N / benzene / 16 h / 20 °C

2: 95 percent / toluene / 110 °C

With triethylamine; In toluene; benzene; 2: Diels-Alder cycloaddition;
DOI:10.1021/jo025924e