[(3R,4S)-1-{5-[1-(3-ethyl-[1,2,4]triazolo[4,3-c]pyrimidin-7-yl)piperidin-4-ylmethoxy]pyrimidin-2-yl}-4-(2,4,5-trifluorophenyl)pyrrolidin-3-yl]carbamic acid tert-butyl ester

Base Information

Chemical Name:[(3R,4S)-1-{5-[1-(3-ethyl-[1,2,4]triazolo[4,3-c]pyrimidin-7-yl)piperidin-4-ylmethoxy]pyrimidin-2-yl}-4-(2,4,5-trifluorophenyl)pyrrolidin-3-yl]carbamic acid tert-butyl ester
CAS No.:1351342-33-0
Molecular Formula:C₃₂H₃₈F₃N₉O₃
Molecular Weight:653.707
Hs Code.:

[(3R,4S)-1-{5-[1-(3-ethyl-[1,2,4]triazolo[4,3-c]pyrimidin-7-yl)piperidin-4-ylmethoxy]pyrimidin-2-yl}-4-(2,4,5-trifluorophenyl)pyrrolidin-3-yl]carbamic acid tert-butyl ester

Synonyms:[(3R,4S)-1-{5-[1-(3-ethyl-[1,2,4]triazolo[4,3-c]pyrimidin-7-yl)piperidin-4-ylmethoxy]pyrimidin-2-yl}-4-(2,4,5-trifluorophenyl)pyrrolidin-3-yl]carbamic acid tert-butyl ester

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Chemical Property of [(3R,4S)-1-{5-[1-(3-ethyl-[1,2,4]triazolo[4,3-c]pyrimidin-7-yl)piperidin-4-ylmethoxy]pyrimidin-2-yl}-4-(2,4,5-trifluorophenyl)pyrrolidin-3-yl]carbamic acid tert-butyl ester

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Technology Process of [(3R,4S)-1-{5-[1-(3-ethyl-[1,2,4]triazolo[4,3-c]pyrimidin-7-yl)piperidin-4-ylmethoxy]pyrimidin-2-yl}-4-(2,4,5-trifluorophenyl)pyrrolidin-3-yl]carbamic acid tert-butyl ester

There total 8 articles about [(3R,4S)-1-{5-[1-(3-ethyl-[1,2,4]triazolo[4,3-c]pyrimidin-7-yl)piperidin-4-ylmethoxy]pyrimidin-2-yl}-4-(2,4,5-trifluorophenyl)pyrrolidin-3-yl]carbamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1351342-07-8
[1-(3-ethyl-[1,2,4]triazolo[4,3-c]pyrimidin-7-yl)piperidin-4-yl]methanol

: 1351341-86-0
[(3R,4S)-4-(2,4,5-trifluorophenyl)-1-(5-hydroxypyrimidin-2-yl)pyrrolidin-3-yl]carbamic acid tert-butyl ester

: 1351342-33-0
[(3R,4S)-1-{5-[1-(3-ethyl-[1,2,4]triazolo[4,3-c]pyrimidin-7-yl)piperidin-4-ylmethoxy]pyrimidin-2-yl}-4-(2,4,5-trifluorophenyl)pyrrolidin-3-yl]carbamic acid tert-butyl ester

Guidance literature:: [1-(3-ethyl-[1,2,4]triazolo[4,3-c]pyrimidin-7-yl)piperidin-4-yl]methanol; With methanesulfonyl chloride; triethylamine; In dichloromethane; at 20 ℃; for 2h;

[(3R,4S)-4-(2,4,5-trifluorophenyl)-1-(5-hydroxypyrimidin-2-yl)pyrrolidin-3-yl]carbamic acid tert-butyl ester; With potassium carbonate; In N,N-dimethyl-formamide; at 80 ℃; for 16h;

Reference yield:

: 915100-83-3
[(3R,4S)-4-(2,4,5-trifluorophenyl)pyrrolidin-3-yl]carbamic acid tert-butyl ester

: 1351342-33-0
[(3R,4S)-1-{5-[1-(3-ethyl-[1,2,4]triazolo[4,3-c]pyrimidin-7-yl)piperidin-4-ylmethoxy]pyrimidin-2-yl}-4-(2,4,5-trifluorophenyl)pyrrolidin-3-yl]carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 4 h / 150 °C / microwave irradiation

2.1: hydrogen / palladium 10% on activated carbon / ethanol / 1 h / Inert atmosphere

3.1: triethylamine; methanesulfonyl chloride / dichloromethane / 2 h / 20 °C

3.2: 16 h / 80 °C

With hydrogen; methanesulfonyl chloride; triethylamine; N-ethyl-N,N-diisopropylamine; palladium 10% on activated carbon; In ethanol; dichloromethane; acetonitrile;

Reference yield:

: 936251-01-3
[(trans)-1-benzyl-4-(2,4,5-trifluorophenyl)pyrrolidin-3-yl]carbamic acid tert-butyl ester

: 1351342-33-0
[(3R,4S)-1-{5-[1-(3-ethyl-[1,2,4]triazolo[4,3-c]pyrimidin-7-yl)piperidin-4-ylmethoxy]pyrimidin-2-yl}-4-(2,4,5-trifluorophenyl)pyrrolidin-3-yl]carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: hydrogen / 5%-palladium/activated carbon / toluene; industrial methylated spirit / 72 h / Inert atmosphere; autoclave

2.1: (2S)-2-(6-methoxy(2-naphthyl))propanoic acid / ethanol / 20 °C / Reflux

3.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 4 h / 150 °C / microwave irradiation

4.1: hydrogen / palladium 10% on activated carbon / ethanol / 1 h / Inert atmosphere

5.1: triethylamine; methanesulfonyl chloride / dichloromethane / 2 h / 20 °C

5.2: 16 h / 80 °C

With hydrogen; (2S)-2-(6-methoxy(2-naphthyl))propanoic acid; methanesulfonyl chloride; triethylamine; N-ethyl-N,N-diisopropylamine; 5%-palladium/activated carbon; palladium 10% on activated carbon; In industrial methylated spirit; ethanol; dichloromethane; toluene; acetonitrile;