ethyl 3-(2-iodophenyl)-2-[methyl-(2-methylamino-3-phenylpropionyl)amino]propionate

Base Information

Chemical Name:ethyl 3-(2-iodophenyl)-2-[methyl-(2-methylamino-3-phenylpropionyl)amino]propionate
CAS No.:943926-27-0
Molecular Formula:C₂₂H₂₇IN₂O₃
Molecular Weight:494.372
Hs Code.:

Synonyms:ethyl 3-(2-iodophenyl)-2-[methyl-(2-methylamino-3-phenylpropionyl)amino]propionate

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Chemical Property of ethyl 3-(2-iodophenyl)-2-[methyl-(2-methylamino-3-phenylpropionyl)amino]propionate

Chemical Property:

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Technology Process of ethyl 3-(2-iodophenyl)-2-[methyl-(2-methylamino-3-phenylpropionyl)amino]propionate

There total 4 articles about ethyl 3-(2-iodophenyl)-2-[methyl-(2-methylamino-3-phenylpropionyl)amino]propionate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 943926-26-9
ethyl 2-{[2-(tert-butoxycarbonyl(methyl)amino)-3-phenylpropionyl]methylamino}3-(2-iodophenyl)propionate

: 943926-27-0
ethyl 3-(2-iodophenyl)-2-[methyl-(2-methylamino-3-phenylpropionyl)amino]propionate

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 2h;

Reference yield:

: 943926-24-7
ethyl 2-(tert-butoxycarbonylmethylamino)-3-(2-iodophenyl)propionate

: 943926-27-0
ethyl 3-(2-iodophenyl)-2-[methyl-(2-methylamino-3-phenylpropionyl)amino]propionate

Guidance literature:: Multi-step reaction with 3 steps

1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

2: N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 16 h

3: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

With N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane;

Reference yield:

: 145060-76-0
tert-butoxycarbonyl-methyl-amino-acetic acid ethyl ester

: 943926-27-0
ethyl 3-(2-iodophenyl)-2-[methyl-(2-methylamino-3-phenylpropionyl)amino]propionate

Guidance literature:: Multi-step reaction with 4 steps

1.1: lithium diisopropyl amide / tetrahydrofuran; n-heptane / 2 h / -78 °C

1.2: 13 h / -78 - 20 °C

2.1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

3.1: N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 16 h

4.1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

With N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; lithium diisopropyl amide; In tetrahydrofuran; n-heptane; dichloromethane;