(S)-N-Benzyloxycarbonyl-4-aminotryptophan methyl ester

Base Information

Chemical Name:(S)-N-Benzyloxycarbonyl-4-aminotryptophan methyl ester
CAS No.:252289-09-1
Molecular Formula:C₂₀H₂₁N₃O₄
Molecular Weight:367.404
Hs Code.:

Synonyms:(S)-N-Benzyloxycarbonyl-4-aminotryptophan methyl ester

Suppliers and Price of (S)-N-Benzyloxycarbonyl-4-aminotryptophan methyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (S)-N-Benzyloxycarbonyl-4-aminotryptophan methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (S)-N-Benzyloxycarbonyl-4-aminotryptophan methyl ester

There total 12 articles about (S)-N-Benzyloxycarbonyl-4-aminotryptophan methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.4%

: 252289-08-0
(S)-N-Benzyloxycarbonyl-4-(N-tert-butyloxycarbonyl)aminotryptophan methyl ester

: 252289-09-1
(S)-N-Benzyloxycarbonyl-4-aminotryptophan methyl ester

Guidance literature:: With trifluoroacetic acid;
DOI:10.1002/(SICI)1521-3773(19991004)38:19<2902::AID-ANIE2902>3.0.CO;2-2

Reference yield:

: 146886-51-3
1-(N-triisopropylsilyl-1H-indol-3-yl)-N,N-dimethylmethanamine

: 252289-09-1
(S)-N-Benzyloxycarbonyl-4-aminotryptophan methyl ester

Guidance literature:: Multi-step reaction with 10 steps

1.1: tBuLi / diethyl ether / 1.75 h / -78 - 0 °C

1.2: 73 percent / diethyl ether / 1 h / -78 °C

2.1: 91.7 percent / tetrahydrofuran / 20 °C

3.1: MeI / dimethylformamide / 20 °C

4.1: 6.51 g / TBAF / tetrahydrofuran / 1 h / 20 °C

5.1: morpholine / Pd[PPh₃]4 / tetrahydrofuran / 0.5 h / 20 °C

6.1: 3.42 g / dioxane / 0.5 h / Heating

7.1: 39 percent / aq. NaOH; penicillin G acylase / aq. methanol / 37 °C / pH 7.6

8.1: dioxane; aq. NaOH / 1 h / 20 °C

9.1: 0.903 g / methanol; CH₂Cl₂ / 0.5 h / 20 °C

10.1: 91.4 percent / CF₃COOH / various solvent(s) / 0.5 h / 20 °C

With morpholine; sodium hydroxide; penicillin G acylase; tetrabutyl ammonium fluoride; tert.-butyl lithium; trifluoroacetic acid; methyl iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; methanol; sodium hydroxide; diethyl ether; dichloromethane; N,N-dimethyl-formamide; 4.1: Mannich-type reaction;
DOI:10.1002/1521-3765(20001103)6:21<3943::AID-CHEM3943<3.3.CO;2-K

Reference yield:

: 146886-61-5
3-Dimethylaminomethyl-4-amino-1-triisopropylsilylindole

: 252289-09-1
(S)-N-Benzyloxycarbonyl-4-aminotryptophan methyl ester

Guidance literature:: Multi-step reaction with 9 steps

1: 91.7 percent / tetrahydrofuran / 20 °C

2: MeI / dimethylformamide / 20 °C

3: 6.51 g / TBAF / tetrahydrofuran / 1 h / 20 °C

4: morpholine / Pd[PPh₃]4 / tetrahydrofuran / 0.5 h / 20 °C

5: 3.42 g / dioxane / 0.5 h / Heating

6: 39 percent / aq. NaOH; penicillin G acylase / aq. methanol / 37 °C / pH 7.6

7: dioxane; aq. NaOH / 1 h / 20 °C

8: 0.903 g / methanol; CH₂Cl₂ / 0.5 h / 20 °C

9: 91.4 percent / CF₃COOH / various solvent(s) / 0.5 h / 20 °C

With morpholine; sodium hydroxide; penicillin G acylase; tetrabutyl ammonium fluoride; trifluoroacetic acid; methyl iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; methanol; sodium hydroxide; dichloromethane; N,N-dimethyl-formamide; 3: Mannich-type reaction;
DOI:10.1002/1521-3765(20001103)6:21<3943::AID-CHEM3943<3.3.CO;2-K