(R)-2-(tert-butyldimethylsilyloxy)-4-iodo-1-phenoxybutane

Base Information

• Chemical Name: (R)-2-(tert-butyldimethylsilyloxy)-4-iodo-1-phenoxybutane
• CAS No.: 333968-37-9
• Molecular Formula: C₁₆H₂₇IO₂Si
• Molecular Weight: 406.379
• Mol file: 333968-37-9.mol

Synonyms:(R)-2-(tert-butyldimethylsilyloxy)-4-iodo-1-phenoxybutane

Chemical Property of (R)-2-(tert-butyldimethylsilyloxy)-4-iodo-1-phenoxybutane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-2-(tert-butyldimethylsilyloxy)-4-iodo-1-phenoxybutane

There total 3 articles about (R)-2-(tert-butyldimethylsilyloxy)-4-iodo-1-phenoxybutane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

phenol (108-95-2,27073-41-2) → (R)-2-(tert-butyldimethylsilyloxy)-4-iodo-1-phenoxybutane (333968-37-9)

Guidance literature:

Multi-step reaction with 3 steps

1: 99 percent / tert-butyl methyl ester; molecular sieves 4 Angstroem / (S,S)-(salen)Co[OC(CF₃)3] / 16 h / -20 °C

2: imidazole / dimethylformamide / 48 h / 20 °C

3: 3.21 g / NaI / acetone / Heating

With 1H-imidazole; tert-butyl methyl ester; 4 A molecular sieve; sodium iodide; (S,S)-(salen)Co[OC(CF₃)3]; In N,N-dimethyl-formamide; acetone;

DOI:10.1021/ol015613a

Reference yield:

(3-bromo-1-phenoxymethyl-propoxy)-tert-butyl-dimethyl-silane → (R)-2-(tert-butyldimethylsilyloxy)-4-iodo-1-phenoxybutane (333968-37-9)

Guidance literature:

With sodium iodide; In acetone; Heating;

DOI:10.1021/ol015613a

Reference yield:

(R)-4-Bromo-1-phenoxy-butan-2-ol (333968-38-0) → (R)-2-(tert-butyldimethylsilyloxy)-4-iodo-1-phenoxybutane (333968-37-9)

Guidance literature:

Multi-step reaction with 2 steps

1: imidazole / dimethylformamide / 48 h / 20 °C

2: 3.21 g / NaI / acetone / Heating

With 1H-imidazole; sodium iodide; In N,N-dimethyl-formamide; acetone;

DOI:10.1021/ol015613a

upstream raw materials:

(R)-4-Bromo-1-phenoxy-butan-2-ol

phenol

Downstream raw materials:

2-[4-(benzyloxy)butyl]-4-(tert-butyldimethylsilyloxy)-3-[3-(tert-butyldimethylsilyloxy)-4-phenoxybutyl]-cyclopentan-1-one

{4-[3,5-dihydroxy-2-(3-hydroxy-4-phenoxybutyl)-cyclopentyl]butylthio}acetic acid

benzyl N-methyl-{4-[3,5-dihydroxy-2-(3-hydroxy-4-phenoxybutyl)cyclopentyl]butylamino}acetate

4-{3,5-bis(tert-butyldimethylsilyloxy)-2-[3-(tert-butyldimethylsilyloxy)-4-phenoxybutyl]cyclopentyl}butanal