(S)-tert-butyl-N-[3-(4-chlorobenzylthio)-1-(dimethoxyphosphoryloxy)propan-2-yl]carbamate

Base Information

Chemical Name:(S)-tert-butyl-N-[3-(4-chlorobenzylthio)-1-(dimethoxyphosphoryloxy)propan-2-yl]carbamate
CAS No.:952196-88-2
Molecular Formula:C₁₇H₂₇ClNO₆PS
Molecular Weight:439.897
Hs Code.:

Synonyms:(S)-tert-butyl-N-[3-(4-chlorobenzylthio)-1-(dimethoxyphosphoryloxy)propan-2-yl]carbamate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-tert-butyl-N-[3-(4-chlorobenzylthio)-1-(dimethoxyphosphoryloxy)propan-2-yl]carbamate

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Technology Process of (S)-tert-butyl-N-[3-(4-chlorobenzylthio)-1-(dimethoxyphosphoryloxy)propan-2-yl]carbamate

There total 4 articles about (S)-tert-butyl-N-[3-(4-chlorobenzylthio)-1-(dimethoxyphosphoryloxy)propan-2-yl]carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 952196-79-1
(S)-tert-butyl-N-[3-(4-chlorobenzylthio)-1-hydroxypropan-2-yl]carbamate

: 813-77-4
Dimethyl chlorophosphate

: 952196-88-2
(S)-tert-butyl-N-[3-(4-chlorobenzylthio)-1-(dimethoxyphosphoryloxy)propan-2-yl]carbamate

Guidance literature:: With 1-methyl-1H-imidazole; In dichloromethane; at 20 ℃; for 24h;
DOI:10.1080/00397910701466030

Reference yield:

: 935547-66-3
4(S)-4-(4-chlorobenzylthiomethyl)-2,2-dimethyloxazolidine-3-carboxylic acid tert-butyl ester

: 952196-88-2
(S)-tert-butyl-N-[3-(4-chlorobenzylthio)-1-(dimethoxyphosphoryloxy)propan-2-yl]carbamate

Guidance literature:: Multi-step reaction with 2 steps

1: 75 percent / pTsOH / methanol / 3 h / 20 °C

2: 78 percent / N-methylimidazole / CH₂Cl₂ / 24 h / 20 °C

With 1-methyl-1H-imidazole; toluene-4-sulfonic acid; In methanol; dichloromethane;
DOI:10.1080/00397910701466030

Reference yield:

: 6258-66-8
(4-chlorophenyl)methanethiol

: 952196-88-2
(S)-tert-butyl-N-[3-(4-chlorobenzylthio)-1-(dimethoxyphosphoryloxy)propan-2-yl]carbamate

Guidance literature:: Multi-step reaction with 3 steps

1: NaH / dimethylformamide / 60 - 80 °C

2: 75 percent / pTsOH / methanol / 3 h / 20 °C

3: 78 percent / N-methylimidazole / CH₂Cl₂ / 24 h / 20 °C

With 1-methyl-1H-imidazole; sodium hydride; toluene-4-sulfonic acid; In methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1080/00397910701466030