Benzeneacetamide, -alpha--hydroxy-2-methoxy-6-methyl-

Base Information

• Chemical Name: Benzeneacetamide, -alpha--hydroxy-2-methoxy-6-methyl-
• CAS No.: 100948-55-8
• Molecular Formula: C10H13 N O3
• Molecular Weight: 195.22
• Mol file: 100948-55-8.mol

Synonyms:Benzeneacetamide,a-hydroxy-2-methoxy-6-methyl-, (?à)-

Chemical Property of Benzeneacetamide, -alpha--hydroxy-2-methoxy-6-methyl-

Chemical Property:

• PSA: 72.55000
• LogP: 1.22260

Purity/Quality:

98%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Benzeneacetamide, -alpha--hydroxy-2-methoxy-6-methyl-

There total 4 articles about Benzeneacetamide, -alpha--hydroxy-2-methoxy-6-methyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-acetoxy-2-(2-methoxy-6-methylphenyl)thioacetic acid methyl ester (100948-57-0) → 2-hydroxy-(2-methoxy-6-methylphenyl)acetamide (100948-55-8)

Guidance literature:

With ammonium hydroxide; In ethanol; for 55h; Yield given;

DOI:10.1021/jm00155a030

Reference yield:

1-methoxy-1,3-cyclohexadiene (2161-90-2) → 2-hydroxy-(2-methoxy-6-methylphenyl)acetamide (100948-55-8)

Guidance literature:

Multi-step reaction with 4 steps

1: 32 percent / 96 h / 110 °C

2: 1.) NaH / 1.) 75 deg C, 2 h, 2.) THF, RT, 1.5 h

3: acetic anhydride / toluene / 24 h / 100 °C

4: conc. aq. NH₄OH / ethanol / 55 h

With ammonium hydroxide; acetic anhydride; sodium hydride; In ethanol; toluene;

DOI:10.1021/jm00155a030

Reference yield:

ethyl 2-methoxy-6-methylbenzoate (6520-83-8) → 2-hydroxy-(2-methoxy-6-methylphenyl)acetamide (100948-55-8)

Guidance literature:

Multi-step reaction with 3 steps

1: 1.) NaH / 1.) 75 deg C, 2 h, 2.) THF, RT, 1.5 h

2: acetic anhydride / toluene / 24 h / 100 °C

3: conc. aq. NH₄OH / ethanol / 55 h

With ammonium hydroxide; acetic anhydride; sodium hydride; In ethanol; toluene;

DOI:10.1021/jm00155a030

upstream raw materials:

2-acetoxy-2-(2-methoxy-6-methylphenyl)thioacetic acid methyl ester

1-methoxy-1,3-cyclohexadiene

ethyl 2-methoxy-6-methylbenzoate

2-Methanesulfinyl-1-(2-methoxy-6-methyl-phenyl)-ethanone

Downstream raw materials:

5-(2-methoxy-6-methylphenyl)oxazolidine-2,4-dione

Refernces