4β-[3-(3-chlorobenzoyl)thioureido]-4'-O-demethyl-4-desoxypodophyllotoxin

Base Information

Chemical Name:4β-[3-(3-chlorobenzoyl)thioureido]-4'-O-demethyl-4-desoxypodophyllotoxin
CAS No.:1278585-96-8
Molecular Formula:C₂₉H₂₅ClN₂O₈S
Molecular Weight:597.045
Hs Code.:

Synonyms:4β-[3-(3-chlorobenzoyl)thioureido]-4'-O-demethyl-4-desoxypodophyllotoxin

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4β-[3-(3-chlorobenzoyl)thioureido]-4'-O-demethyl-4-desoxypodophyllotoxin

Chemical Property:

Purity/Quality:

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Technology Process of 4β-[3-(3-chlorobenzoyl)thioureido]-4'-O-demethyl-4-desoxypodophyllotoxin

There total 4 articles about 4β-[3-(3-chlorobenzoyl)thioureido]-4'-O-demethyl-4-desoxypodophyllotoxin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: 66090-36-6
3-chlorobenzoyl isothiocyanate

: 117507-84-3
(5R,5aR,8aS,9S)-9-amino-5-(4-hydroxy-3,5-dimethoxyphenyl)-5,5a,8a,9-tetrahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol-6(8H)-one

: 1278585-96-8
4β-[3-(3-chlorobenzoyl)thioureido]-4'-O-demethyl-4-desoxypodophyllotoxin

Guidance literature:: In acetonitrile; for 2h; Reflux;
DOI:10.1016/j.ejmech.2011.01.001

Reference yield:

: 518-28-5
podofilox

: 1278585-96-8
4β-[3-(3-chlorobenzoyl)thioureido]-4'-O-demethyl-4-desoxypodophyllotoxin

Guidance literature:: Multi-step reaction with 4 steps

1: 1-(Trimethylsilyl)imidazole / dichloromethane / 0 °C

2: hydrogen azide; boron trifluoride diethyl etherate

3: palladium on carbon; hydrogen / ethyl acetate

4: acetonitrile / 2 h / Reflux

With hydrogen azide; palladium on carbon; boron trifluoride diethyl etherate; hydrogen; 1-(Trimethylsilyl)imidazole; In dichloromethane; ethyl acetate; acetonitrile;
DOI:10.1016/j.ejmech.2011.01.001

Reference yield:

: 6559-91-7
4'-demethylepipodophyllotoxin

: 1278585-96-8
4β-[3-(3-chlorobenzoyl)thioureido]-4'-O-demethyl-4-desoxypodophyllotoxin

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogen azide; boron trifluoride diethyl etherate

2: palladium on carbon; hydrogen / ethyl acetate

3: acetonitrile / 2 h / Reflux

With hydrogen azide; palladium on carbon; boron trifluoride diethyl etherate; hydrogen; In ethyl acetate; acetonitrile;
DOI:10.1016/j.ejmech.2011.01.001