(2R,3S,5R)-5-(2-oxo-6-(4-pentylphenyl)furo[2,3-d]pyrimidin-3(2H)-yl)-2-(hydroxymethyl)-tetrahydrofuran-3-yl 2-chloroacetate

Base Information

Chemical Name:(2R,3S,5R)-5-(2-oxo-6-(4-pentylphenyl)furo[2,3-d]pyrimidin-3(2H)-yl)-2-(hydroxymethyl)-tetrahydrofuran-3-yl 2-chloroacetate
CAS No.:1370288-87-1
Molecular Formula:C₂₄H₂₇ClN₂O₆
Molecular Weight:474.941
Hs Code.:

Synonyms:(2R,3S,5R)-5-(2-oxo-6-(4-pentylphenyl)furo[2,3-d]pyrimidin-3(2H)-yl)-2-(hydroxymethyl)-tetrahydrofuran-3-yl 2-chloroacetate

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Chemical Property of (2R,3S,5R)-5-(2-oxo-6-(4-pentylphenyl)furo[2,3-d]pyrimidin-3(2H)-yl)-2-(hydroxymethyl)-tetrahydrofuran-3-yl 2-chloroacetate

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Technology Process of (2R,3S,5R)-5-(2-oxo-6-(4-pentylphenyl)furo[2,3-d]pyrimidin-3(2H)-yl)-2-(hydroxymethyl)-tetrahydrofuran-3-yl 2-chloroacetate

There total 5 articles about (2R,3S,5R)-5-(2-oxo-6-(4-pentylphenyl)furo[2,3-d]pyrimidin-3(2H)-yl)-2-(hydroxymethyl)-tetrahydrofuran-3-yl 2-chloroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1370288-86-0
(2R,3S,5R)-5-(2-oxo-6-(4-pentylphenyl)furo[2,3-d]pyrimidin-3(2H)-yl)-2-((tert-butyldimethylsilyloxy)methyl)-tetrahydrofuran-3-yl benzyl carbonate

: 1370288-87-1
(2R,3S,5R)-5-(2-oxo-6-(4-pentylphenyl)furo[2,3-d]pyrimidin-3(2H)-yl)-2-(hydroxymethyl)-tetrahydrofuran-3-yl 2-chloroacetate

Guidance literature:: With hydrogenchloride; water; In ethanol; ethyl acetate;

Reference yield:

: 1370288-93-9
(2R,3S,5R)-5-(2-oxo-6-(4-pentylphenyl)furo[2,3-d]pyrimidin-3(2H)-yl)-2-(bis(4-methoxyphenyl)(phenyl)methoxy-methyl)-tetrahydrofuran-3-yl-2-chloroacetate

: 1370288-87-1
(2R,3S,5R)-5-(2-oxo-6-(4-pentylphenyl)furo[2,3-d]pyrimidin-3(2H)-yl)-2-(hydroxymethyl)-tetrahydrofuran-3-yl 2-chloroacetate

Guidance literature:: With water; acetic acid; at 30 - 35 ℃; Product distribution / selectivity; Large scale;

Reference yield:

: 3-(5-((tert-butyldimethylsilyloxy)methyl)-4-hydroxy-tetrahydrofuran-2-yl)-6-(4-pentylphenyl)furo[2,3-d]pyrimidin-2(3H)-one

: 1370288-87-1
(2R,3S,5R)-5-(2-oxo-6-(4-pentylphenyl)furo[2,3-d]pyrimidin-3(2H)-yl)-2-(hydroxymethyl)-tetrahydrofuran-3-yl 2-chloroacetate

Guidance literature:: Multi-step reaction with 2 steps

1: dmap / dichloromethane / 6 h / 20 °C

2: hydrogenchloride; water / ethyl acetate; ethanol

With hydrogenchloride; dmap; water; In ethanol; dichloromethane; ethyl acetate;