(2R,3S,5R)-5-(2-oxo-6-(4-pentylphenyl)furo[2,3-d]pyrimidin-3(2H)-yl)-2-(bis(4-methoxyphenyl)(phenyl)methoxy-methyl)-tetrahydrofuran-3-yl-2-chloroacetate

Base Information

Chemical Name:(2R,3S,5R)-5-(2-oxo-6-(4-pentylphenyl)furo[2,3-d]pyrimidin-3(2H)-yl)-2-(bis(4-methoxyphenyl)(phenyl)methoxy-methyl)-tetrahydrofuran-3-yl-2-chloroacetate
CAS No.:1370288-93-9
Molecular Formula:C₄₅H₄₅ClN₂O₈
Molecular Weight:777.314
Hs Code.:

(2R,3S,5R)-5-(2-oxo-6-(4-pentylphenyl)furo[2,3-d]pyrimidin-3(2H)-yl)-2-(bis(4-methoxyphenyl)(phenyl)methoxy-methyl)-tetrahydrofuran-3-yl-2-chloroacetate

Synonyms:(2R,3S,5R)-5-(2-oxo-6-(4-pentylphenyl)furo[2,3-d]pyrimidin-3(2H)-yl)-2-(bis(4-methoxyphenyl)(phenyl)methoxy-methyl)-tetrahydrofuran-3-yl-2-chloroacetate

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Chemical Property of (2R,3S,5R)-5-(2-oxo-6-(4-pentylphenyl)furo[2,3-d]pyrimidin-3(2H)-yl)-2-(bis(4-methoxyphenyl)(phenyl)methoxy-methyl)-tetrahydrofuran-3-yl-2-chloroacetate

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Technology Process of (2R,3S,5R)-5-(2-oxo-6-(4-pentylphenyl)furo[2,3-d]pyrimidin-3(2H)-yl)-2-(bis(4-methoxyphenyl)(phenyl)methoxy-methyl)-tetrahydrofuran-3-yl-2-chloroacetate

There total 3 articles about (2R,3S,5R)-5-(2-oxo-6-(4-pentylphenyl)furo[2,3-d]pyrimidin-3(2H)-yl)-2-(bis(4-methoxyphenyl)(phenyl)methoxy-methyl)-tetrahydrofuran-3-yl-2-chloroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1370288-84-8
3-((2R,4S,5R)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-hydroxy-tetrahydrofuran-2-yl)-6-(4-pentylphenyl)furo[2,3-d]Pyrimidin-2(3H)-one

: 79-04-9
chloroacetyl chloride

: 1370288-93-9
(2R,3S,5R)-5-(2-oxo-6-(4-pentylphenyl)furo[2,3-d]pyrimidin-3(2H)-yl)-2-(bis(4-methoxyphenyl)(phenyl)methoxy-methyl)-tetrahydrofuran-3-yl-2-chloroacetate

Guidance literature:: With dmap; at 20 ℃; Large scale;

Reference yield:

: 40615-36-9
4,4'-dimethoxytrityl chloride

: 1370288-93-9
(2R,3S,5R)-5-(2-oxo-6-(4-pentylphenyl)furo[2,3-d]pyrimidin-3(2H)-yl)-2-(bis(4-methoxyphenyl)(phenyl)methoxy-methyl)-tetrahydrofuran-3-yl-2-chloroacetate

Guidance literature:: Multi-step reaction with 2 steps

1: pyridine / dichloromethane / 20 °C / Large scale

2: dmap / 20 °C / Large scale

With pyridine; dmap; In dichloromethane;

Reference yield:

: 3-((2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)-tetrahydrofuran-2-yl)-6-(4-pentylphenyl)furo[2,3-d]pyrimidin-2(3H)-one

: 1370288-93-9
(2R,3S,5R)-5-(2-oxo-6-(4-pentylphenyl)furo[2,3-d]pyrimidin-3(2H)-yl)-2-(bis(4-methoxyphenyl)(phenyl)methoxy-methyl)-tetrahydrofuran-3-yl-2-chloroacetate

Guidance literature:: Multi-step reaction with 2 steps

1: pyridine / dichloromethane / 20 °C / Large scale

2: dmap / 20 °C / Large scale

With pyridine; dmap; In dichloromethane;