N-L-Dab-O-(4,4'-dimethoxytrityl)-O'-(tert-butyldimethylsilyl)diethanolamine

Base Information

Chemical Name:N-L-Dab-O-(4,4'-dimethoxytrityl)-O'-(tert-butyldimethylsilyl)diethanolamine
CAS No.:745796-05-8
Molecular Formula:C₃₅H₅₁N₃O₅Si
Molecular Weight:621.893
Hs Code.:

Synonyms:N-L-Dab-O-(4,4'-dimethoxytrityl)-O'-(tert-butyldimethylsilyl)diethanolamine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-L-Dab-O-(4,4'-dimethoxytrityl)-O'-(tert-butyldimethylsilyl)diethanolamine

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Technology Process of N-L-Dab-O-(4,4'-dimethoxytrityl)-O'-(tert-butyldimethylsilyl)diethanolamine

There total 5 articles about N-L-Dab-O-(4,4'-dimethoxytrityl)-O'-(tert-butyldimethylsilyl)diethanolamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: 745796-04-7
N-(N^α,N^ε-bis-Fmoc-L-Dab)-O-(4,4'-dimethoxytrityl)-O'-(tert-butyldimethylsilyl)diethanolamine

: 745796-05-8
N-L-Dab-O-(4,4'-dimethoxytrityl)-O'-(tert-butyldimethylsilyl)diethanolamine

Guidance literature:: With piperidine; In N,N-dimethyl-formamide; at 20 ℃; for 1h;
DOI:10.1021/ja049061d

Reference yield:

: 40615-36-9
4,4'-dimethoxytrityl chloride

: 745796-05-8
N-L-Dab-O-(4,4'-dimethoxytrityl)-O'-(tert-butyldimethylsilyl)diethanolamine

Guidance literature:: Multi-step reaction with 4 steps

1: 43 percent / pyridine / 2 h / 20 °C

2: 84 percent / imidazole / dimethylformamide / 2 h / 20 °C

3: 76 percent / PyBOP; diisopropylethylamine / dimethylformamide / 1 h / 20 °C

4: 69 percent / piperidine / dimethylformamide / 1 h / 20 °C

With piperidine; 1H-imidazole; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In pyridine; N,N-dimethyl-formamide;
DOI:10.1021/ja049061d

Reference yield:

: 18162-48-6
tert-butyldimethylsilyl chloride

: 745796-05-8
N-L-Dab-O-(4,4'-dimethoxytrityl)-O'-(tert-butyldimethylsilyl)diethanolamine

Guidance literature:: Multi-step reaction with 3 steps

1: 84 percent / imidazole / dimethylformamide / 2 h / 20 °C

2: 76 percent / PyBOP; diisopropylethylamine / dimethylformamide / 1 h / 20 °C

3: 69 percent / piperidine / dimethylformamide / 1 h / 20 °C

With piperidine; 1H-imidazole; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide;
DOI:10.1021/ja049061d