(S)-2-Amino-4-methyl-pentanoic acid [3-cyano-1-(2,2-difluoro-ethyl)-2-oxo-3-(triphenyl-λ⁵-phosphanylidene)-propyl]-amide

Base Information

• Chemical Name: (S)-2-Amino-4-methyl-pentanoic acid [3-cyano-1-(2,2-difluoro-ethyl)-2-oxo-3-(triphenyl-λ⁵-phosphanylidene)-propyl]-amide
• CAS No.: 262437-60-5
• Molecular Formula: C₃₀H₃₂F₂N₃O₂P
• Molecular Weight: 535.574

Synonyms:(S)-2-Amino-4-methyl-pentanoic acid [3-cyano-1-(2,2-difluoro-ethyl)-2-oxo-3-(triphenyl-λ⁵-phosphanylidene)-propyl]-amide

Chemical Property of (S)-2-Amino-4-methyl-pentanoic acid [3-cyano-1-(2,2-difluoro-ethyl)-2-oxo-3-(triphenyl-λ⁵-phosphanylidene)-propyl]-amide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-2-Amino-4-methyl-pentanoic acid [3-cyano-1-(2,2-difluoro-ethyl)-2-oxo-3-(triphenyl-λ⁵-phosphanylidene)-propyl]-amide

There total 5 articles about (S)-2-Amino-4-methyl-pentanoic acid [3-cyano-1-(2,2-difluoro-ethyl)-2-oxo-3-(triphenyl-λ⁵-phosphanylidene)-propyl]-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

{(S)-1-[3-Cyano-1-(2,2-difluoro-ethyl)-2-oxo-3-(triphenyl-λ5-phosphanylidene)-propylcarbamoyl]-3-methyl-butyl}-carbamic acid benzyl ester (438202-60-9) → (S)-2-Amino-4-methyl-pentanoic acid [3-cyano-1-(2,2-difluoro-ethyl)-2-oxo-3-(triphenyl-λ5-phosphanylidene)-propyl]-amide (262437-60-5)

Guidance literature:

With ammonium formate; palladium on activated charcoal; In methanol;

DOI:10.1016/S0960-894X(01)00843-5

Reference yield:

Z-Leu-OH (2018-66-8) → (S)-2-Amino-4-methyl-pentanoic acid [3-cyano-1-(2,2-difluoro-ethyl)-2-oxo-3-(triphenyl-λ5-phosphanylidene)-propyl]-amide (262437-60-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 88 percent / EDCI; HOBt / CH₂Cl₂

2: 78 percent / NH₄CO₂ / Pd/C / methanol

With ammonium formate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; palladium on activated charcoal; In methanol; dichloromethane;

DOI:10.1016/S0960-894X(01)00843-5

Reference yield:

cyanomethylene triphenylphosphorane (16640-68-9) → (S)-2-Amino-4-methyl-pentanoic acid [3-cyano-1-(2,2-difluoro-ethyl)-2-oxo-3-(triphenyl-λ5-phosphanylidene)-propyl]-amide (262437-60-5)

Guidance literature:

Multi-step reaction with 4 steps

1: 82 percent / EDCI; HOBt / CH₂Cl₂

2: 80 percent / NH₄CO₂ / Pd/C / methanol

3: 88 percent / EDCI; HOBt / CH₂Cl₂

4: 78 percent / NH₄CO₂ / Pd/C / methanol

With ammonium formate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; palladium on activated charcoal; In methanol; dichloromethane;

DOI:10.1016/S0960-894X(01)00843-5

upstream raw materials:

{(S)-1-[3-Cyano-1-(2,2-difluoro-ethyl)-2-oxo-3-(triphenyl-λ⁵-phosphanylidene)-propylcarbamoyl]-3-methyl-butyl}-carbamic acid benzyl ester

Z-Leu-OH

cyanomethylene triphenylphosphorane

(R,S)-4-amino-6,6-difluoro-3-oxo-2-triphenylphosphoranylidene-hexanenitrile

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 262437-60-5 (S)-2-Amino-4-methyl-pentanoic acid [3-cyano-1-(2,2-difluoro-ethyl)-2-oxo-3-(triphenyl-λ⁵-phosphanylidene)-propyl]-amide

Send

Send

Metric Ton KG G Pound L ML

Send

Send