DES-TYR1-LEUCINE ENKEPHALINAMIDE ACETATE SALT

Base Information

• Chemical Name: DES-TYR1-LEUCINE ENKEPHALINAMIDE ACETATE SALT
• CAS No.: 100929-57-5
• Molecular Formula: C21H33N5O6
• Molecular Weight: 451.52
• Mol file: 100929-57-5.mol

Synonyms:GLY-GLY-PHE-LEU-NH2 ACETATE SALT;DES-TYR1-LEUCINE ENKEPHALINAMIDE ACETATE SALT;des-tyr-1-leucine enkephalinamide*acetate;gly-gly-phe-leu-nh2;(des-tyrosine1)leucine enkephalinamide

Chemical Property of DES-TYR1-LEUCINE ENKEPHALINAMIDE ACETATE SALT

Chemical Property:

• PSA: 205.17000
• LogP: 3.26680
• Storage Temp.: −20°C

Purity/Quality:

99%min ^*data from raw suppliers

[DES-TYR1]-LEUCINE ENKEPHALINAMIDE ACETATE SALT 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of DES-TYR1-LEUCINE ENKEPHALINAMIDE ACETATE SALT

There total 4 articles about DES-TYR1-LEUCINE ENKEPHALINAMIDE ACETATE SALT which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-benzyloxycarbonyl-L-glycyl-L-glycyl-L-phenylalanine (13171-93-2) → Glycylglycylphenylalanylleucinamide acetate (100929-57-5)

Guidance literature:

Multi-step reaction with 3 steps

1: N-methylmorpholine / tetrahydrofuran / 0.17 h / -20 °C

2: tetrahydrofuran; H₂O; dimethylformamide / 1 h / Ambient temperature

3: hydrogen / 10percent Pd/C / methanol / 8 h / Ambient temperature

With 4-methyl-morpholine; hydrogen; palladium on activated charcoal; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide;

DOI:10.1021/jm00160a039

Reference yield:

(2S)-amino-4-methylpentanamide hydrochloride (10466-61-2) → Glycylglycylphenylalanylleucinamide acetate (100929-57-5)

Guidance literature:

Multi-step reaction with 2 steps

1: tetrahydrofuran; H₂O; dimethylformamide / 1 h / Ambient temperature

2: hydrogen / 10percent Pd/C / methanol / 8 h / Ambient temperature

With hydrogen; palladium on activated charcoal; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide;

DOI:10.1021/jm00160a039

Reference yield:

C26H31N3O8 → Glycylglycylphenylalanylleucinamide acetate (100929-57-5)

Guidance literature:

Multi-step reaction with 2 steps

1: tetrahydrofuran; H₂O; dimethylformamide / 1 h / Ambient temperature

2: hydrogen / 10percent Pd/C / methanol / 8 h / Ambient temperature

With hydrogen; palladium on activated charcoal; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide;

DOI:10.1021/jm00160a039

upstream raw materials:

Z-Gly-Gly-L-Phe-L-Leu-NH₂

acetic acid

N-benzyloxycarbonyl-L-glycyl-L-glycyl-L-phenylalanine

(2S)-amino-4-methylpentanamide hydrochloride

Refernces