Carbamic acid, [(1R)-2-amino-1-methylethyl]-, 1,1-dimethylethyl ester (9CI)

Base Information

Chemical Name:Carbamic acid, [(1R)-2-amino-1-methylethyl]-, 1,1-dimethylethyl ester (9CI)
CAS No.:100927-10-4
Molecular Formula:C8H18 N2 O2
Molecular Weight:174.243
Hs Code.:2924199090
Mol file:100927-10-4.mol

Synonyms:Carbamicacid, (2-amino-1-methylethyl)-, 1,1-dimethylethyl ester, (R)-; Carbamic acid, [(1R)-2-amino-1-methylethyl]-,1,1-dimethylethyl ester (9CI)

Suppliers and Price of Carbamic acid, [(1R)-2-amino-1-methylethyl]-, 1,1-dimethylethyl ester (9CI)

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
(R)-1-Aminopropan-2-ylcarbamicAcidtert-ButyEster
1g
$ 1320.00

Matrix Scientific
tert-Butyl (1R)-2-amino-1-methylethylcarbamate
5g
$ 1206.00

Matrix Scientific
tert-Butyl (1R)-2-amino-1-methylethylcarbamate
10g
$ 1602.00

Matrix Scientific
tert-Butyl (1R)-2-amino-1-methylethylcarbamate
1g
$ 432.00

Crysdot
(R)-tert-Butyl(1-aminopropan-2-yl)carbamate 98%
5g
$ 594.00

Biosynth Carbosynth
(R)-tert-Butyl (1-aminopropan-2-yl)carbamate
100 mg
$ 250.00

Biosynth Carbosynth
(R)-tert-Butyl (1-aminopropan-2-yl)carbamate
250 mg
$ 300.00

Biosynth Carbosynth
(R)-tert-Butyl (1-aminopropan-2-yl)carbamate
500 mg
$ 350.00

Biosynth Carbosynth
(R)-tert-Butyl (1-aminopropan-2-yl)carbamate
1 g
$ 550.00

Biosynth Carbosynth
(R)-tert-Butyl (1-aminopropan-2-yl)carbamate
2 g
$ 700.00

Total 34 raw suppliers

Chemical Property of Carbamic acid, [(1R)-2-amino-1-methylethyl]-, 1,1-dimethylethyl ester (9CI)

Chemical Property:

Vapor Pressure:0.000874mmHg at 25°C
Boiling Point:264℃
PKA:12.19±0.46(Predicted)
Flash Point:113℃
PSA：64.35000
Density:0.984
LogP:2.75150
Storage Temp.:2-8°C(protect from light)

Purity/Quality:

97% ^*data from raw suppliers

(R)-1-Aminopropan-2-ylcarbamicAcidtert-ButyEster ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Uses (R)-1-Aminopropan-2-ylcarbamic Acid tert-Buty Ester is used as an intermediate in the preparation of potent benzothiophene inhibitors of mitogen activated protein kinase-activated protein kinase 2 (MK 2).

Technology Process of Carbamic acid, [(1R)-2-amino-1-methylethyl]-, 1,1-dimethylethyl ester (9CI)

There total 9 articles about Carbamic acid, [(1R)-2-amino-1-methylethyl]-, 1,1-dimethylethyl ester (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 146610-69-7
1-azido-(S)-2-(N-tert-butoxycarbonyl)aminopropane

: 100927-10-4
tert-butyl N-[(1R)-2-amino-1-methyl-ethyl]carbamate

Guidance literature:: With palladium 10% on activated carbon; hydrogen; In ethyl acetate; at 20 ℃; for 15h; under 760.051 Torr;

Reference yield: 84.0%

: 78981-25-6
N-(tert-butoxycarbonyl)-D-alanine amide

: 100927-10-4
tert-butyl N-[(1R)-2-amino-1-methyl-ethyl]carbamate

Guidance literature:: With dimethylsulfide borane complex; In tetrahydrofuran; at 0 - 20 ℃; for 18h; Inert atmosphere;
DOI:10.1039/c5ob00819k

Reference yield:

: 79069-13-9,127516-56-7,147252-84-4,106391-86-0
(R)-2-tertbutoxycarbonylamino-1-propanol

: 100927-10-4
tert-butyl N-[(1R)-2-amino-1-methyl-ethyl]carbamate

Guidance literature:: Multi-step reaction with 2 steps

1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran; toluene / 6 h / 20 °C / Cooling with ice

2: hydrazine hydrate / ethanol / 3 h / Reflux

With hydrazine hydrate; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; ethanol; toluene;
DOI:10.1271/bbb.100846