2-[(2-chloro-5-fluoro-4-pyridinyl)amino]-N-methylbenzamide

Base Information

• Chemical Name: 2-[(2-chloro-5-fluoro-4-pyridinyl)amino]-N-methylbenzamide
• CAS No.: 1184931-53-0
• Molecular Formula: C₁₃H₁₁ClFN₃O
• Molecular Weight: 279.701
• Mol file: 1184931-53-0.mol

Synonyms:2-[(2-chloro-5-fluoro-4-pyridinyl)amino]-N-methylbenzamide

Chemical Property of 2-[(2-chloro-5-fluoro-4-pyridinyl)amino]-N-methylbenzamide

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of 2-[(2-chloro-5-fluoro-4-pyridinyl)amino]-N-methylbenzamide

There total 1 articles about 2-[(2-chloro-5-fluoro-4-pyridinyl)amino]-N-methylbenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

2-chloro-5-fluoro-4-iodopyridine (884494-49-9) + 2-Amino-N-methylbenzamid (4141-08-6) → 2-[(2-chloro-5-fluoro-4-pyridinyl)amino]-N-methylbenzamide (1184931-53-0)

Guidance literature:

With caesium carbonate; palladium diacetate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; at 80 ℃; for 24h; Inert atmosphere;

Reference yield: 64.0%

2-[(2-chloro-5-fluoro-4-pyridinyl)amino]-N-methylbenzamide (1184931-53-0) + 2-(4-amino-1H-pyrazol-1-yl)acetic acid dihydrochloride (1201935-99-0) → 2-[4-[[5-fluoro-4-[[2-(methylcarbamoyl)phenyl]amino]pyridin-2-yl]amino]pyrazol-1-yl]acetic acid (1201935-63-8)

Guidance literature:

2-(4-amino-1H-pyrazol-1-yl)acetic acid dihydrochloride; With sodium t-butanolate; In 1,4-dioxane; at 22 ℃; for 0.0833333h; Inert atmosphere; Sonication;

2-[(2-chloro-5-fluoro-4-pyridinyl)amino]-N-methylbenzamide; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; at 22 - 150 ℃; for 1h; Inert atmosphere; Microwave irradiation;

Reference yield: 42.0%

2-[(2-chloro-5-fluoro-4-pyridinyl)amino]-N-methylbenzamide (1184931-53-0) + 1-methyl-4-aminopyrazole (69843-13-6) → 2-((5-fluoro-2-((1-methylpyrazol-4-yl)amino)-4-pyridyl)amino)-N-methyl-benzamide (1201934-31-7)

Guidance literature:

With sodium t-butanolate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; bis(dibenzylideneacetone)-palladium⁽⁰⁾; In 1,4-dioxane; at 150 ℃; for 0.5h; Microwave irradiation; Inert atmosphere;

upstream raw materials:

2-chloro-5-fluoro-4-iodopyridine

2-Amino-N-methylbenzamid

Downstream raw materials:

2-({5-fluoro-2-[(2-oxo-2,3-dihydro-1H-indol-5-yl)amino]-4-pyridinyl}amino)-N-methylbenzamide

2-[(5-fluoro-2-{[2-(methyloxy)-4-(4-morpholinyl)phenyl]amino}-4-pyridinyl)amino]-N-methylbenzamide

2-((5-fluoro-2-((1-methylpyrazol-4-yl)amino)-4-pyridyl)amino)-N-methyl-benzamide

2-[4-[[5-fluoro-4-[[2-(methylcarbamoyl)phenyl]amino]pyridin-2-yl]amino]pyrazol-1-yl]acetic acid