(3R,4S)-4-Benzyloxy-5-(tert-butyl-diphenyl-silanyloxy)-3-(tert-butyl-diphenyl-silanyloxymethyl)-pent-1-en-3-ol

Base Information

Chemical Name:(3R,4S)-4-Benzyloxy-5-(tert-butyl-diphenyl-silanyloxy)-3-(tert-butyl-diphenyl-silanyloxymethyl)-pent-1-en-3-ol
CAS No.:201553-26-6
Molecular Formula:C₄₅H₅₄O₄Si₂
Molecular Weight:715.092
Hs Code.:

Synonyms:(3R,4S)-4-Benzyloxy-5-(tert-butyl-diphenyl-silanyloxy)-3-(tert-butyl-diphenyl-silanyloxymethyl)-pent-1-en-3-ol

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Chemical Property of (3R,4S)-4-Benzyloxy-5-(tert-butyl-diphenyl-silanyloxy)-3-(tert-butyl-diphenyl-silanyloxymethyl)-pent-1-en-3-ol

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Technology Process of (3R,4S)-4-Benzyloxy-5-(tert-butyl-diphenyl-silanyloxy)-3-(tert-butyl-diphenyl-silanyloxymethyl)-pent-1-en-3-ol

There total 6 articles about (3R,4S)-4-Benzyloxy-5-(tert-butyl-diphenyl-silanyloxy)-3-(tert-butyl-diphenyl-silanyloxymethyl)-pent-1-en-3-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 1826-67-1
vinyl magnesium bromide

: 183888-69-9
(3R)-3-benzyloxy-1,4-bis(tert-butyl-diphenyl-silyloxy)butan-2-one

: 201553-26-6
(3R,4S)-4-Benzyloxy-5-(tert-butyl-diphenyl-silanyloxy)-3-(tert-butyl-diphenyl-silanyloxymethyl)-pent-1-en-3-ol

Guidance literature:: In tetrahydrofuran; at -78 ℃; for 1h;
DOI:10.1021/jo9716744

Reference yield:

: 91274-01-0
2-O-benzyl-1-O-trityl-L-threitol

: 201553-26-6
(3R,4S)-4-Benzyloxy-5-(tert-butyl-diphenyl-silanyloxy)-3-(tert-butyl-diphenyl-silanyloxymethyl)-pent-1-en-3-ol

Guidance literature:: Multi-step reaction with 5 steps

1: 70 percent / Et₃N, DMAP / CH₂Cl₂ / 18 h / Ambient temperature

2: 1.) DMSO, oxalyl chloride, 2.) Et₃N / 1.) CH₂Cl₂, -60 deg C, 15 min, 2.) CH₂Cl₂, -60 deg C, 15 min, 25 deg C, 1 h

3: 90 percent / tetrahydrofuran / 1 h / -78 °C

4: concd. HCl / tetrahydrofuran; methanol / 18 h / Ambient temperature

5: Et₃N, DMAP / CH₂Cl₂

With hydrogenchloride; dmap; oxalyl dichloride; dimethyl sulfoxide; triethylamine; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1021/jo9716744

Reference yield:

: 201553-32-4
(3R,4S)-4-Benzyloxy-5-trityloxy-3-trityloxymethyl-pent-1-en-3-ol

: 201553-26-6
(3R,4S)-4-Benzyloxy-5-(tert-butyl-diphenyl-silanyloxy)-3-(tert-butyl-diphenyl-silanyloxymethyl)-pent-1-en-3-ol

Guidance literature:: Multi-step reaction with 2 steps

1: concd. HCl / tetrahydrofuran; methanol / 18 h / Ambient temperature

2: Et₃N, DMAP / CH₂Cl₂

With hydrogenchloride; dmap; triethylamine; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1021/jo9716744