(2R,3R)-N-((7S)-3,3-difluoro-6-oxo-9-phenyl-3,4,6,7-tetrahydro-2H-[1,4]diazepino[1,7,6-ef][1,5]benzoxazepin-7-yl)-3-(3-methyl-4-isoxazolyl)-2-(3,3,3-trifluoropropyl)succinamide

Base Information

Chemical Name:(2R,3R)-N-((7S)-3,3-difluoro-6-oxo-9-phenyl-3,4,6,7-tetrahydro-2H-[1,4]diazepino[1,7,6-ef][1,5]benzoxazepin-7-yl)-3-(3-methyl-4-isoxazolyl)-2-(3,3,3-trifluoropropyl)succinamide
CAS No.:1582184-06-2
Molecular Formula:C₂₉H₂₆F₅N₅O₅
Molecular Weight:619.548
Hs Code.:

(2R,3R)-N-((7S)-3,3-difluoro-6-oxo-9-phenyl-3,4,6,7-tetrahydro-2H-[1,4]diazepino[1,7,6-ef][1,5]benzoxazepin-7-yl)-3-(3-methyl-4-isoxazolyl)-2-(3,3,3-trifluoropropyl)succinamide

Synonyms:(2R,3R)-N-((7S)-3,3-difluoro-6-oxo-9-phenyl-3,4,6,7-tetrahydro-2H-[1,4]diazepino[1,7,6-ef][1,5]benzoxazepin-7-yl)-3-(3-methyl-4-isoxazolyl)-2-(3,3,3-trifluoropropyl)succinamide

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Chemical Property of (2R,3R)-N-((7S)-3,3-difluoro-6-oxo-9-phenyl-3,4,6,7-tetrahydro-2H-[1,4]diazepino[1,7,6-ef][1,5]benzoxazepin-7-yl)-3-(3-methyl-4-isoxazolyl)-2-(3,3,3-trifluoropropyl)succinamide

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Technology Process of (2R,3R)-N-((7S)-3,3-difluoro-6-oxo-9-phenyl-3,4,6,7-tetrahydro-2H-[1,4]diazepino[1,7,6-ef][1,5]benzoxazepin-7-yl)-3-(3-methyl-4-isoxazolyl)-2-(3,3,3-trifluoropropyl)succinamide

There total 18 articles about (2R,3R)-N-((7S)-3,3-difluoro-6-oxo-9-phenyl-3,4,6,7-tetrahydro-2H-[1,4]diazepino[1,7,6-ef][1,5]benzoxazepin-7-yl)-3-(3-methyl-4-isoxazolyl)-2-(3,3,3-trifluoropropyl)succinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.9%

: 1582185-21-4
(2R,3R)-3-(((S)-6,6-difluoro-8-oxo-11-phenyl-6,7,8,9-tetrahydro-5H-4-oxa-7a,10-diazabenzo[ef]heptalen-9-yl)carbamoyl)-6,6,6-trifluoro-2-(3-methylisoxazol-4-yl)hexanoic acid

: 1582184-06-2
(2R,3R)-N-((7S)-3,3-difluoro-6-oxo-9-phenyl-3,4,6,7-tetrahydro-2H-[1,4]diazepino[1,7,6-ef][1,5]benzoxazepin-7-yl)-3-(3-methyl-4-isoxazolyl)-2-(3,3,3-trifluoropropyl)succinamide

Guidance literature:: (2R,3R)-3-(((S)-6,6-difluoro-8-oxo-11-phenyl-6,7,8,9-tetrahydro-5H-4-oxa-7a,10-diazabenzo[ef]heptalen-9-yl)carbamoyl)-6,6,6-trifluoro-2-(3-methylisoxazol-4-yl)hexanoic acid; With benzotriazol-1-ol; In tetrahydrofuran; for 0.333333h;

With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; at 20 ℃; for 0.25h;

With ammonia; In tetrahydrofuran; isopropyl alcohol; at 0 - 20 ℃; for 16.3333h;

Reference yield:

: 3177-80-8
2-amino-3-methoxybenzoic acid

: 1582184-06-2
(2R,3R)-N-((7S)-3,3-difluoro-6-oxo-9-phenyl-3,4,6,7-tetrahydro-2H-[1,4]diazepino[1,7,6-ef][1,5]benzoxazepin-7-yl)-3-(3-methyl-4-isoxazolyl)-2-(3,3,3-trifluoropropyl)succinamide

Guidance literature:: Multi-step reaction with 12 steps

1.1: 3 h / 140 °C

2.1: tetrahydrofuran; toluene; diethyl ether / 0 - 20 °C

2.2: 100 °C

3.1: triethylamine / dichloromethane / 1.92 h / 0 - 20 °C

3.2: 16 h

3.3: 5 h

4.1: boron tribromide / dichloromethane / 16 h / 20 °C

5.1: triethylamine / 1,4-dioxane / 4 h / 20 °C

6.1: caesium carbonate / N,N-dimethyl-formamide / 4 h / 20 °C

7.1: diethylamino-sulfur trifluoride / 16 h / 0 - 20 °C

8.1: CHIRALPAK? OJ-H / methanol / Resolution of racemate

9.1: hydrogenchloride; water / dichloromethane; 1,4-dioxane / 5 h

10.1: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine / N,N-dimethyl-formamide / 1 h / 20 °C

11.1: trifluoroacetic acid / dichloromethane / 5 h / 20 °C

12.1: benzotriazol-1-ol / tetrahydrofuran / 0.33 h

12.2: 0.25 h / 20 °C

12.3: 16.33 h / 0 - 20 °C

With hydrogenchloride; diethylamino-sulfur trifluoride; water; boron tribromide; benzotriazol-1-ol; caesium carbonate; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; trifluoroacetic acid; In tetrahydrofuran; 1,4-dioxane; methanol; diethyl ether; dichloromethane; N,N-dimethyl-formamide; toluene;

Reference yield:

: 54905-94-1
8-methoxy-2-methyl-4H-benzo[d][1,3]oxazin-4-one

: 1582184-06-2
(2R,3R)-N-((7S)-3,3-difluoro-6-oxo-9-phenyl-3,4,6,7-tetrahydro-2H-[1,4]diazepino[1,7,6-ef][1,5]benzoxazepin-7-yl)-3-(3-methyl-4-isoxazolyl)-2-(3,3,3-trifluoropropyl)succinamide

Guidance literature:: Multi-step reaction with 11 steps

1.1: tetrahydrofuran; toluene; diethyl ether / 0 - 20 °C

1.2: 100 °C

2.1: triethylamine / dichloromethane / 1.92 h / 0 - 20 °C

2.2: 16 h

2.3: 5 h

3.1: boron tribromide / dichloromethane / 16 h / 20 °C

4.1: triethylamine / 1,4-dioxane / 4 h / 20 °C

5.1: caesium carbonate / N,N-dimethyl-formamide / 4 h / 20 °C

6.1: diethylamino-sulfur trifluoride / 16 h / 0 - 20 °C

7.1: CHIRALPAK? OJ-H / methanol / Resolution of racemate

8.1: hydrogenchloride; water / dichloromethane; 1,4-dioxane / 5 h

9.1: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine / N,N-dimethyl-formamide / 1 h / 20 °C

10.1: trifluoroacetic acid / dichloromethane / 5 h / 20 °C

11.1: benzotriazol-1-ol / tetrahydrofuran / 0.33 h

11.2: 0.25 h / 20 °C

11.3: 16.33 h / 0 - 20 °C

With hydrogenchloride; diethylamino-sulfur trifluoride; water; boron tribromide; benzotriazol-1-ol; caesium carbonate; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; trifluoroacetic acid; In tetrahydrofuran; 1,4-dioxane; methanol; diethyl ether; dichloromethane; N,N-dimethyl-formamide; toluene;