tert-butyl {(3R)-1-[3-(2-chlorobenzyl)-7-(iodomethyl)-5-methyl-4-oxo-4,5-dihydro-3H-imidazo[4,5-c]quinolin-2-yl]piperidin-3-yl}carbamate

Base Information

Chemical Name:tert-butyl {(3R)-1-[3-(2-chlorobenzyl)-7-(iodomethyl)-5-methyl-4-oxo-4,5-dihydro-3H-imidazo[4,5-c]quinolin-2-yl]piperidin-3-yl}carbamate
CAS No.:1404555-69-6
Molecular Formula:C₂₉H₃₃ClIN₅O₃
Molecular Weight:661.97
Hs Code.:

Synonyms:tert-butyl {(3R)-1-[3-(2-chlorobenzyl)-7-(iodomethyl)-5-methyl-4-oxo-4,5-dihydro-3H-imidazo[4,5-c]quinolin-2-yl]piperidin-3-yl}carbamate

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Chemical Property of tert-butyl {(3R)-1-[3-(2-chlorobenzyl)-7-(iodomethyl)-5-methyl-4-oxo-4,5-dihydro-3H-imidazo[4,5-c]quinolin-2-yl]piperidin-3-yl}carbamate

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Technology Process of tert-butyl {(3R)-1-[3-(2-chlorobenzyl)-7-(iodomethyl)-5-methyl-4-oxo-4,5-dihydro-3H-imidazo[4,5-c]quinolin-2-yl]piperidin-3-yl}carbamate

There total 7 articles about tert-butyl {(3R)-1-[3-(2-chlorobenzyl)-7-(iodomethyl)-5-methyl-4-oxo-4,5-dihydro-3H-imidazo[4,5-c]quinolin-2-yl]piperidin-3-yl}carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 25.0%

: 853069-58-6
tert-butyl {(3R)-1-[3-(2-chlorobenzyl)-7-(hydroxymethyl)-5-methyl-4-oxo-4,5-dihydro-3H-imidazo[4,5-c]quinolin-2-yl]piperidin-3-yl}carbamate

: 1404555-69-6
tert-butyl {(3R)-1-[3-(2-chlorobenzyl)-7-(iodomethyl)-5-methyl-4-oxo-4,5-dihydro-3H-imidazo[4,5-c]quinolin-2-yl]piperidin-3-yl}carbamate

Guidance literature:: With 1H-imidazole; iodine; triphenylphosphine; In tetrahydrofuran; at 20 ℃; for 16h;
DOI:10.1016/j.bmc.2012.07.046

Reference yield:

: 853070-06-1
C₃₂H₃₉ClIN₅O₅

: 1404555-69-6
tert-butyl {(3R)-1-[3-(2-chlorobenzyl)-7-(iodomethyl)-5-methyl-4-oxo-4,5-dihydro-3H-imidazo[4,5-c]quinolin-2-yl]piperidin-3-yl}carbamate

Guidance literature:: Multi-step reaction with 6 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 12 h / 20 °C

2.1: silver (I) hydrogen carbonate; palladium diacetate; triphenylphosphine / N,N-dimethyl-formamide / 1 h / 150 °C

3.1: hydrogenchloride / 1,4-dioxane / 4 h / 80 °C

4.1: sodium hydrogencarbonate / tetrahydrofuran; water / 3 h / 20 °C

5.1: chloroformic acid ethyl ester; triethylamine / tetrahydrofuran / 1.5 h / 0 °C

5.2: 5 h / 0 - 20 °C

6.1: 1H-imidazole; iodine; triphenylphosphine / tetrahydrofuran / 16 h / 20 °C

With 1H-imidazole; hydrogenchloride; silver (I) hydrogen carbonate; iodine; palladium diacetate; chloroformic acid ethyl ester; sodium hydrogencarbonate; potassium carbonate; triethylamine; triphenylphosphine; In tetrahydrofuran; 1,4-dioxane; water; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2012.07.046

Reference yield:

: 853069-84-8
tert-butyl 3-[{[2-{(3R)-3-[(tert-butoxycarbonyl)amino]piperidin-1-yl}-1-(2-chlorobenzyl)-4-iodo-1H-imidazol-5-yl]carbonyl}(methyl)amino]benzoate

: 1404555-69-6
tert-butyl {(3R)-1-[3-(2-chlorobenzyl)-7-(iodomethyl)-5-methyl-4-oxo-4,5-dihydro-3H-imidazo[4,5-c]quinolin-2-yl]piperidin-3-yl}carbamate

Guidance literature:: Multi-step reaction with 5 steps

1.1: silver (I) hydrogen carbonate; palladium diacetate; triphenylphosphine / N,N-dimethyl-formamide / 1 h / 150 °C

2.1: hydrogenchloride / 1,4-dioxane / 4 h / 80 °C

3.1: sodium hydrogencarbonate / tetrahydrofuran; water / 3 h / 20 °C

4.1: chloroformic acid ethyl ester; triethylamine / tetrahydrofuran / 1.5 h / 0 °C

4.2: 5 h / 0 - 20 °C

5.1: 1H-imidazole; iodine; triphenylphosphine / tetrahydrofuran / 16 h / 20 °C

With 1H-imidazole; hydrogenchloride; silver (I) hydrogen carbonate; iodine; palladium diacetate; chloroformic acid ethyl ester; sodium hydrogencarbonate; triethylamine; triphenylphosphine; In tetrahydrofuran; 1,4-dioxane; water; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2012.07.046