tert-butyl 3-[{[2-{(3R)-3-[(tert-butoxycarbonyl)amino]piperidin-1-yl}-1-(2-chlorobenzyl)-4-iodo-1H-imidazol-5-yl]carbonyl}(methyl)amino]benzoate

Base Information

Chemical Name:tert-butyl 3-[{[2-{(3R)-3-[(tert-butoxycarbonyl)amino]piperidin-1-yl}-1-(2-chlorobenzyl)-4-iodo-1H-imidazol-5-yl]carbonyl}(methyl)amino]benzoate
CAS No.:853069-84-8
Molecular Formula:C₃₃H₄₁ClIN₅O₅
Molecular Weight:750.077
Hs Code.:

Synonyms:tert-butyl 3-[{[2-{(3R)-3-[(tert-butoxycarbonyl)amino]piperidin-1-yl}-1-(2-chlorobenzyl)-4-iodo-1H-imidazol-5-yl]carbonyl}(methyl)amino]benzoate

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Chemical Property of tert-butyl 3-[{[2-{(3R)-3-[(tert-butoxycarbonyl)amino]piperidin-1-yl}-1-(2-chlorobenzyl)-4-iodo-1H-imidazol-5-yl]carbonyl}(methyl)amino]benzoate

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Technology Process of tert-butyl 3-[{[2-{(3R)-3-[(tert-butoxycarbonyl)amino]piperidin-1-yl}-1-(2-chlorobenzyl)-4-iodo-1H-imidazol-5-yl]carbonyl}(methyl)amino]benzoate

There total 2 articles about tert-butyl 3-[{[2-{(3R)-3-[(tert-butoxycarbonyl)amino]piperidin-1-yl}-1-(2-chlorobenzyl)-4-iodo-1H-imidazol-5-yl]carbonyl}(methyl)amino]benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 853070-06-1
C₃₂H₃₉ClIN₅O₅

: 74-88-4
methyl iodide

: 853069-84-8
tert-butyl 3-[{[2-{(3R)-3-[(tert-butoxycarbonyl)amino]piperidin-1-yl}-1-(2-chlorobenzyl)-4-iodo-1H-imidazol-5-yl]carbonyl}(methyl)amino]benzoate

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 12h;
DOI:10.1016/j.bmc.2012.07.046

Reference yield:

: 853069-84-8
tert-butyl 3-[{[2-{(3R)-3-[(tert-butoxycarbonyl)amino]piperidin-1-yl}-1-(2-chlorobenzyl)-4-iodo-1H-imidazol-5-yl]carbonyl}(methyl)amino]benzoate

Guidance literature:

Reference yield:

: 853069-84-8
tert-butyl 3-[{[2-{(3R)-3-[(tert-butoxycarbonyl)amino]piperidin-1-yl}-1-(2-chlorobenzyl)-4-iodo-1H-imidazol-5-yl]carbonyl}(methyl)amino]benzoate

: 1404555-69-6
tert-butyl {(3R)-1-[3-(2-chlorobenzyl)-7-(iodomethyl)-5-methyl-4-oxo-4,5-dihydro-3H-imidazo[4,5-c]quinolin-2-yl]piperidin-3-yl}carbamate

Guidance literature:: Multi-step reaction with 5 steps

1.1: silver (I) hydrogen carbonate; palladium diacetate; triphenylphosphine / N,N-dimethyl-formamide / 1 h / 150 °C

2.1: hydrogenchloride / 1,4-dioxane / 4 h / 80 °C

3.1: sodium hydrogencarbonate / tetrahydrofuran; water / 3 h / 20 °C

4.1: chloroformic acid ethyl ester; triethylamine / tetrahydrofuran / 1.5 h / 0 °C

4.2: 5 h / 0 - 20 °C

5.1: 1H-imidazole; iodine; triphenylphosphine / tetrahydrofuran / 16 h / 20 °C

With 1H-imidazole; hydrogenchloride; silver (I) hydrogen carbonate; iodine; palladium diacetate; chloroformic acid ethyl ester; sodium hydrogencarbonate; triethylamine; triphenylphosphine; In tetrahydrofuran; 1,4-dioxane; water; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2012.07.046