(2R,4R)-2-(2-acetoxyphenyl)-3-(tert-butoxycarbonyl)thiazolidine-4-carboxamide

Base Information

Chemical Name:(2R,4R)-2-(2-acetoxyphenyl)-3-(tert-butoxycarbonyl)thiazolidine-4-carboxamide
CAS No.:161153-18-0
Molecular Formula:C₁₉H₂₅N₃O₈S
Molecular Weight:455.489
Hs Code.:

(2R,4R)-2-(2-acetoxyphenyl)-3-(tert-butoxycarbonyl)thiazolidine-4-<N-(2-nitrooxyethyl)>carboxamide

Synonyms:(2R,4R)-2-(2-acetoxyphenyl)-3-(tert-butoxycarbonyl)thiazolidine-4-carboxamide

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Chemical Property of (2R,4R)-2-(2-acetoxyphenyl)-3-(tert-butoxycarbonyl)thiazolidine-4-carboxamide

Chemical Property:

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Technology Process of (2R,4R)-2-(2-acetoxyphenyl)-3-(tert-butoxycarbonyl)thiazolidine-4-carboxamide

There total 3 articles about (2R,4R)-2-(2-acetoxyphenyl)-3-(tert-butoxycarbonyl)thiazolidine-4-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 161153-18-0
(2R,4R)-2-(2-acetoxyphenyl)-3-(tert-butoxycarbonyl)thiazolidine-4-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1: 84 percent / 1N aq. NaOH / tetrahydrofuran / 18 h / Ambient temperature

2: 78 percent / pyridine / 24 h / Ambient temperature

3: 1.) Et₃N, ethyl chloroformate, 2.) Et₃N / 1.) CH₂Cl₂, 0 deg C, 1 h, 2.) CH₂Cl₂, 15 deg C, 1 h

With pyridine; sodium hydroxide; chloroformic acid ethyl ester; triethylamine; In tetrahydrofuran;
DOI:10.1002/jhet.5570310608

Reference yield:

: (2R,4R)-2-(2-hydroxyphenyl)thiazolidine-4-carboxylic acid

: 161153-18-0
(2R,4R)-2-(2-acetoxyphenyl)-3-(tert-butoxycarbonyl)thiazolidine-4-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1: 84 percent / 1N aq. NaOH / tetrahydrofuran / 18 h / Ambient temperature

2: 78 percent / pyridine / 24 h / Ambient temperature

3: 1.) Et₃N, ethyl chloroformate, 2.) Et₃N / 1.) CH₂Cl₂, 0 deg C, 1 h, 2.) CH₂Cl₂, 15 deg C, 1 h

With pyridine; sodium hydroxide; chloroformic acid ethyl ester; triethylamine; In tetrahydrofuran;
DOI:10.1002/jhet.5570310608

Reference yield:

: 161153-16-8
(2R,4R)-3-(tert-butoxycarbonyl)-2-(2-hydroxyphenyl)-thiazolidine-4-carboxylic acid

: 161153-18-0
(2R,4R)-2-(2-acetoxyphenyl)-3-(tert-butoxycarbonyl)thiazolidine-4-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: 78 percent / pyridine / 24 h / Ambient temperature

2: 1.) Et₃N, ethyl chloroformate, 2.) Et₃N / 1.) CH₂Cl₂, 0 deg C, 1 h, 2.) CH₂Cl₂, 15 deg C, 1 h

With pyridine; chloroformic acid ethyl ester; triethylamine;
DOI:10.1002/jhet.5570310608