3-{[7-(4-chloro-3-fluorophenoxy)-4-hydroxyisoquinoline-3-carbonyl]amino}-2,2-dimethylpropionic acid tert-butyl ester

Base Information

Chemical Name:3-{[7-(4-chloro-3-fluorophenoxy)-4-hydroxyisoquinoline-3-carbonyl]amino}-2,2-dimethylpropionic acid tert-butyl ester
CAS No.:1455091-78-7
Molecular Formula:C₂₅H₂₆ClFN₂O₅
Molecular Weight:488.943
Hs Code.:

Synonyms:3-{[7-(4-chloro-3-fluorophenoxy)-4-hydroxyisoquinoline-3-carbonyl]amino}-2,2-dimethylpropionic acid tert-butyl ester

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Chemical Property of 3-{[7-(4-chloro-3-fluorophenoxy)-4-hydroxyisoquinoline-3-carbonyl]amino}-2,2-dimethylpropionic acid tert-butyl ester

Chemical Property:

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Technology Process of 3-{[7-(4-chloro-3-fluorophenoxy)-4-hydroxyisoquinoline-3-carbonyl]amino}-2,2-dimethylpropionic acid tert-butyl ester

There total 5 articles about 3-{[7-(4-chloro-3-fluorophenoxy)-4-hydroxyisoquinoline-3-carbonyl]amino}-2,2-dimethylpropionic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1455091-76-5
7-(4-chloro-3-fluorophenoxy)-4-hydroxyisoquinoline-3-carboxylic acid ethyl ester

: 259794-53-1
3-amino-2,2-dimethylpropionic acid tert-butyl ester

: 1455091-78-7
3-{[7-(4-chloro-3-fluorophenoxy)-4-hydroxyisoquinoline-3-carbonyl]amino}-2,2-dimethylpropionic acid tert-butyl ester

Guidance literature:: In ethanol; at 145 ℃; for 3h; Microwave irradiation;

Reference yield:

: 1455091-74-3
4-(4-chloro-3-fluorophenoxy)-2-{[(2,4-dimethoxybenzyl)(ethoxycarbonylmethyl)amino]methyl}benzoic acid ethyl ester

: 1455091-78-7
3-{[7-(4-chloro-3-fluorophenoxy)-4-hydroxyisoquinoline-3-carbonyl]amino}-2,2-dimethylpropionic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: potassium 2-methylbutan-2-olate / tetrahydrofuran; toluene / 1 h / 20 °C / Cooling with ice

2: ethanol / 3 h / 145 °C / Microwave irradiation

With potassium 2-methylbutan-2-olate; In tetrahydrofuran; ethanol; toluene;

Reference yield:

: 75235-66-4
cyano-dimethylacetic acid tert-butyl ester

: 1455091-78-7
3-{[7-(4-chloro-3-fluorophenoxy)-4-hydroxyisoquinoline-3-carbonyl]amino}-2,2-dimethylpropionic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogen / methanol / 20 °C

2: ethanol / 3 h / 145 °C / Microwave irradiation

With hydrogen; In methanol; ethanol;