Acetamide, N-(6-methoxy-2-benzothiazolyl)- (9CI)

Base Information

• Chemical Name: Acetamide, N-(6-methoxy-2-benzothiazolyl)- (9CI)
• CAS No.: 100817-90-1
• Molecular Formula: C₁₀H₁₀N₂O₂S
• Molecular Weight: 222.268
• Hs Code.: 2934200090
• Mol file: 100817-90-1.mol

Synonyms:Benzothiazole,2-acetamido-6-methoxy- (6CI); N-[6-Methoxybenzo[d]thiazol-2-yl]acetamide

Chemical Property of Acetamide, N-(6-methoxy-2-benzothiazolyl)- (9CI)

Chemical Property:

• PSA: 82.95000
• LogP: 2.91280
• Storage Temp.: 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

N-(6-Methoxybenzo[d]thiazol-2-yl)acetamide 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Acetamide, N-(6-methoxy-2-benzothiazolyl)- (9CI)

There total 6 articles about Acetamide, N-(6-methoxy-2-benzothiazolyl)- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

N-acetyl-N’-(4-methoxyphenyl)thiourea (21258-19-5) → N-(6-methoxybenzo[d]thiazol-2-yl)acetamide (100817-90-1)

Guidance literature:

With copper(l) iodide; caesium carbonate; L-proline; palladium dichloride; In dimethyl sulfoxide; at 100 ℃; for 8h;

DOI:10.1016/j.cclet.2015.08.001

Reference yield: 59.0%

6-methoxybenzothiazol-2-ylamine (1747-60-0) + acetic anhydride (108-24-7) → N-(6-methoxybenzo[d]thiazol-2-yl)acetamide (100817-90-1)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 60 ℃; for 2h; Microwave irradiation;

DOI:10.1021/acs.jmedchem.6b01086

Reference yield:

6-methoxybenzothiazol-2-ylamine (1747-60-0) + acetic acid (64-19-7,77671-22-8) → N-(6-methoxybenzo[d]thiazol-2-yl)acetamide (100817-90-1)

Guidance literature:

for 24h; Reflux;

DOI:10.1016/j.saa.2016.10.007

upstream raw materials:

6-methoxybenzothiazol-2-ylamine

acetic anhydride

N-acetyl-N’-(4-methoxyphenyl)thiourea

4-methoxy-aniline