4-{(R)-carboxy-[5-(4'-hydroxyphenyl)-thiophene-2-sulfonylamino]-methyl}piperidine-1-carboxylic acid iso-propyl ester

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Chemical Name:4-{(R)-carboxy-[5-(4'-hydroxyphenyl)-thiophene-2-sulfonylamino]-methyl}piperidine-1-carboxylic acid iso-propyl ester
CAS No.:458560-20-8
Molecular Formula:C₂₁H₂₆N₂O₇S₂
Molecular Weight:482.579
Hs Code.:

Synonyms:4-{(R)-carboxy-[5-(4'-hydroxyphenyl)-thiophene-2-sulfonylamino]-methyl}piperidine-1-carboxylic acid iso-propyl ester

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Chemical Property of 4-{(R)-carboxy-[5-(4'-hydroxyphenyl)-thiophene-2-sulfonylamino]-methyl}piperidine-1-carboxylic acid iso-propyl ester

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Technology Process of 4-{(R)-carboxy-[5-(4'-hydroxyphenyl)-thiophene-2-sulfonylamino]-methyl}piperidine-1-carboxylic acid iso-propyl ester

There total 2 articles about 4-{(R)-carboxy-[5-(4'-hydroxyphenyl)-thiophene-2-sulfonylamino]-methyl}piperidine-1-carboxylic acid iso-propyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1098299-14-9
(αR)-α-[[[5-(4-hydroxyphenyl)-2-thienyl]sulfonyl]amino]4-piperidineacetic acid

: 108-23-6
isopropyl chloroformate

: 458560-20-8
4-{(R)-carboxy-[5-(4'-hydroxyphenyl)-thiophene-2-sulfonylamino]-methyl}piperidine-1-carboxylic acid iso-propyl ester

Guidance literature:: (αR)-α-[[[5-(4-hydroxyphenyl)-2-thienyl]sulfonyl]amino]4-piperidineacetic acid; With N,O-bis-(trimethylsilyl)-acetamide; In tetrahydrofuran; at 0 ℃;

isopropyl chloroformate; In tetrahydrofuran; toluene; at 0 - 20 ℃;

Reference yield:

: 4-{carboxy-[5-(4'-hydroxyphenyl)-thiophene-2-sulfonylamino]-methyl}piperidine hydrobromide

: 108-23-6
isopropyl chloroformate

: 458560-20-8
4-{(R)-carboxy-[5-(4'-hydroxyphenyl)-thiophene-2-sulfonylamino]-methyl}piperidine-1-carboxylic acid iso-propyl ester

Guidance literature:: 4-{carboxy-[5-(4'-hydroxyphenyl)-thiophene-2-sulfonylamino]-methyl}piperidine hydrobromide; With N,O-bis-(trimethylsilyl)-acetamide; In tetrahydrofuran;

isopropyl chloroformate; In tetrahydrofuran; toluene;
DOI:10.1021/jm801394m