rac-6-(2-(1-(tert-butyldimethylsilyl)-1H-indol-4-yl)propan-2-yl)-3-methyl-2-((trimethylsilyl)oxy)-3-vinylcyclohexanone

Base Information

Chemical Name:rac-6-(2-(1-(tert-butyldimethylsilyl)-1H-indol-4-yl)propan-2-yl)-3-methyl-2-((trimethylsilyl)oxy)-3-vinylcyclohexanone
CAS No.:1352410-70-8
Molecular Formula:C₂₉H₄₇NO₂Si₂
Molecular Weight:497.869
Hs Code.:

Synonyms:rac-6-(2-(1-(tert-butyldimethylsilyl)-1H-indol-4-yl)propan-2-yl)-3-methyl-2-((trimethylsilyl)oxy)-3-vinylcyclohexanone

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Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of rac-6-(2-(1-(tert-butyldimethylsilyl)-1H-indol-4-yl)propan-2-yl)-3-methyl-2-((trimethylsilyl)oxy)-3-vinylcyclohexanone

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of rac-6-(2-(1-(tert-butyldimethylsilyl)-1H-indol-4-yl)propan-2-yl)-3-methyl-2-((trimethylsilyl)oxy)-3-vinylcyclohexanone

There total 6 articles about rac-6-(2-(1-(tert-butyldimethylsilyl)-1H-indol-4-yl)propan-2-yl)-3-methyl-2-((trimethylsilyl)oxy)-3-vinylcyclohexanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 1352410-68-4
C₁₅H₃₀O₂Si₂

: 1352410-69-5
4-(2-hydroxy-2-propyl)-N-TBS-indole

: 1352410-70-8
rac-6-(2-(1-(tert-butyldimethylsilyl)-1H-indol-4-yl)propan-2-yl)-3-methyl-2-((trimethylsilyl)oxy)-3-vinylcyclohexanone

Guidance literature:: With tin(IV) chloride; In dichloromethane; at -78 ℃; for 0.25h;
DOI:10.1021/jo202139k

Reference yield:

: C₁₂H₂₂O₂Si

: 1352410-70-8
rac-6-(2-(1-(tert-butyldimethylsilyl)-1H-indol-4-yl)propan-2-yl)-3-methyl-2-((trimethylsilyl)oxy)-3-vinylcyclohexanone

Guidance literature:: Multi-step reaction with 2 steps

1.1: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / 0 °C

1.2: 0.75 h / 0 °C

2.1: tin(IV) chloride / dichloromethane / 0.25 h / -78 °C

With tin(IV) chloride; lithium hexamethyldisilazane; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jo202139k

Reference yield:

: C₉H₁₄O₂

: 1352410-70-8
rac-6-(2-(1-(tert-butyldimethylsilyl)-1H-indol-4-yl)propan-2-yl)-3-methyl-2-((trimethylsilyl)oxy)-3-vinylcyclohexanone

Guidance literature:: Multi-step reaction with 3 steps

1.1: lithium hexamethyldisilazane / tetrahydrofuran / 1.08 h / -78 - 0 °C

1.2: 0.75 h / 0 °C

2.1: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / 0 °C

2.2: 0.75 h / 0 °C

3.1: tin(IV) chloride / dichloromethane / 0.25 h / -78 °C

With tin(IV) chloride; lithium hexamethyldisilazane; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jo202139k