1-(1,1,7,7-tetraethyl-3,3,5,5-tetramethyl-1,2,3,5,6,7-hexahydros-indacen-4-yl)-3-((R)-(1-phenylethyl))-4,5-dihydroimidazolium trifluoromethanesulfonate

Base Information

Chemical Name:1-(1,1,7,7-tetraethyl-3,3,5,5-tetramethyl-1,2,3,5,6,7-hexahydros-indacen-4-yl)-3-((R)-(1-phenylethyl))-4,5-dihydroimidazolium trifluoromethanesulfonate
CAS No.:1407182-40-4
Molecular Formula:CF₃O₃S*C₃₅H₅₁N₂
Molecular Weight:648.874
Hs Code.:

1-(1,1,7,7-tetraethyl-3,3,5,5-tetramethyl-1,2,3,5,6,7-hexahydros-indacen-4-yl)-3-((R)-(1-phenylethyl))-4,5-dihydroimidazolium trifluoromethanesulfonate

Synonyms:1-(1,1,7,7-tetraethyl-3,3,5,5-tetramethyl-1,2,3,5,6,7-hexahydros-indacen-4-yl)-3-((R)-(1-phenylethyl))-4,5-dihydroimidazolium trifluoromethanesulfonate

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Chemical Property of 1-(1,1,7,7-tetraethyl-3,3,5,5-tetramethyl-1,2,3,5,6,7-hexahydros-indacen-4-yl)-3-((R)-(1-phenylethyl))-4,5-dihydroimidazolium trifluoromethanesulfonate

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Technology Process of 1-(1,1,7,7-tetraethyl-3,3,5,5-tetramethyl-1,2,3,5,6,7-hexahydros-indacen-4-yl)-3-((R)-(1-phenylethyl))-4,5-dihydroimidazolium trifluoromethanesulfonate

There total 8 articles about 1-(1,1,7,7-tetraethyl-3,3,5,5-tetramethyl-1,2,3,5,6,7-hexahydros-indacen-4-yl)-3-((R)-(1-phenylethyl))-4,5-dihydroimidazolium trifluoromethanesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1493-13-6
trifluorormethanesulfonic acid

: 1407182-29-9
(R)-N-(2-(1-phenylethylamino)ethyl)-N-(1,1,7,7-tetraethyl-3,3,5,5-tetramethyl-1,2,3,5,6,7-hexahydros-indacen-4-yl)formamide

: 1407182-40-4
1-(1,1,7,7-tetraethyl-3,3,5,5-tetramethyl-1,2,3,5,6,7-hexahydros-indacen-4-yl)-3-((R)-(1-phenylethyl))-4,5-dihydroimidazolium trifluoromethanesulfonate

Guidance literature:: trifluorormethanesulfonic acid; (R)-N-(2-(1-phenylethylamino)ethyl)-N-(1,1,7,7-tetraethyl-3,3,5,5-tetramethyl-1,2,3,5,6,7-hexahydros-indacen-4-yl)formamide; In toluene; at 20 ℃; for 0.25h;

With trifluoromethylsulfonic anhydride; In toluene; at 20 - 65 ℃; for 1.5h; Further stages;
DOI:10.1039/c2cc36329a

Reference yield:

: 1493-13-6
trifluorormethanesulfonic acid

: 1407182-29-9
(R)-N-(2-(1-phenylethylamino)ethyl)-N-(1,1,7,7-tetraethyl-3,3,5,5-tetramethyl-1,2,3,5,6,7-hexahydros-indacen-4-yl)formamide

: 7087-68-5
N-ethyl-N,N-diisopropylamine

: 1407182-40-4
1-(1,1,7,7-tetraethyl-3,3,5,5-tetramethyl-1,2,3,5,6,7-hexahydros-indacen-4-yl)-3-((R)-(1-phenylethyl))-4,5-dihydroimidazolium trifluoromethanesulfonate

: N,N-diisopropylethylamine trifluoromethanesulfonate

Guidance literature:: trifluorormethanesulfonic acid; (R)-N-(2-(1-phenylethylamino)ethyl)-N-(1,1,7,7-tetraethyl-3,3,5,5-tetramethyl-1,2,3,5,6,7-hexahydros-indacen-4-yl)formamide; In toluene; at 20 ℃; for 0.25h;

With trifluoromethylsulfonic anhydride; In toluene; at 20 - 65 ℃; for 1.5h;

N-ethyl-N,N-diisopropylamine; In toluene; at 65 - 80 ℃; for 1.5h; Sonication;
DOI:10.1039/c2cc36329a

Reference yield:

: 1142818-89-0
1,1,7,7-tetraethyl-1,2,3,5,6,7-hexahydro-3,3,5,5-tetramethyl-s-indacene

: 1407182-40-4
1-(1,1,7,7-tetraethyl-3,3,5,5-tetramethyl-1,2,3,5,6,7-hexahydros-indacen-4-yl)-3-((R)-(1-phenylethyl))-4,5-dihydroimidazolium trifluoromethanesulfonate

Guidance literature:: Multi-step reaction with 7 steps

1.1: nitric acid; acetic anhydride; acetic acid / dichloromethane / 3 h / 0 °C

2.1: methanol; sodium tetrahydroborate; nickel(II) chloride hexahydrate / dichloromethane / 3 h / 0 °C

3.1: n-butyllithium / tetrahydrofuran; hexane / 3 h / 0 - 40 °C

3.2: 18 h / 40 °C

4.1: chloroform / 120 h / 40 °C

5.1: toluene-4-sulfonic acid / toluene; tert-butyl alcohol / 1 h / 100 °C / Inert atmosphere; Microwave irradiation

6.1: sodium cyanoborohydride; acetic acid / dichloromethane; toluene; tert-butyl alcohol / 16 h / 20 °C

7.1: toluene / 0.25 h / 20 °C

7.2: 1.5 h / 20 - 65 °C

With methanol; sodium tetrahydroborate; n-butyllithium; nickel(II) chloride hexahydrate; nitric acid; acetic anhydride; sodium cyanoborohydride; toluene-4-sulfonic acid; acetic acid; In tetrahydrofuran; hexane; dichloromethane; chloroform; toluene; tert-butyl alcohol;
DOI:10.1039/c2cc36329a