2,5-Dihydro-3-<3-(4-hydroxy-3-nitrophenyl)-3-oxo-1-propenyl>-2,2,5,5-tetramethyl-1H-pyrrol-1-yloxyl radical

Base Information

• Chemical Name: 2,5-Dihydro-3-<3-(4-hydroxy-3-nitrophenyl)-3-oxo-1-propenyl>-2,2,5,5-tetramethyl-1H-pyrrol-1-yloxyl radical
• CAS No.: 124558-44-7
• Molecular Formula: C₁₇H₁₉N₂O₅
• Molecular Weight: 331.348
• Mol file: 124558-44-7.mol

Synonyms:2,5-Dihydro-3-<3-(4-hydroxy-3-nitrophenyl)-3-oxo-1-propenyl>-2,2,5,5-tetramethyl-1H-pyrrol-1-yloxyl radical

Chemical Property of 2,5-Dihydro-3-<3-(4-hydroxy-3-nitrophenyl)-3-oxo-1-propenyl>-2,2,5,5-tetramethyl-1H-pyrrol-1-yloxyl radical

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2,5-Dihydro-3-<3-(4-hydroxy-3-nitrophenyl)-3-oxo-1-propenyl>-2,2,5,5-tetramethyl-1H-pyrrol-1-yloxyl radical

There total 5 articles about 2,5-Dihydro-3-<3-(4-hydroxy-3-nitrophenyl)-3-oxo-1-propenyl>-2,2,5,5-tetramethyl-1H-pyrrol-1-yloxyl radical which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

2,5-Dihydro-3-<3-(4-fluoro-3-nitrophenyl)-3-oxo-1-propenyl>-2,2,5,5-tetramethyl-1H-pyrrol-1-yloxyl radical (124558-43-6) → 2,5-Dihydro-3-<3-(4-hydroxy-3-nitrophenyl)-3-oxo-1-propenyl>-2,2,5,5-tetramethyl-1H-pyrrol-1-yloxyl radical (124558-44-7)

Guidance literature:

With sodium hydroxide; In 1,4-dioxane; for 2h; Heating;

DOI:10.1055/s-1989-27306

Reference yield: 10.0%

C17H20NO3 (124558-31-2) → 4-hydroxy-3,5-dinitrobenzoic acid (1019-52-9) + 2,5-Dihydro-3-<3-(4-hydroxy-3-nitrophenyl)-3-oxo-1-propenyl>-2,2,5,5-tetramethyl-1H-pyrrol-1-yloxyl radical (124558-44-7) + 2,5-Dihydro-3-<3-(4-hydroxy-3,5-dinitrophenyl)-3-oxo-1-propenyl>-2,2,5,5-tetramethyl-1H-pyrrol-1-yloxyl radical (124558-45-8)

Guidance literature:

With sulfuric acid; nitric acid; at 0 ℃; for 3h;

DOI:10.1055/s-1989-27306

Reference yield:

3-formyl-2,2,5,5-tetramethyl-pyrroline-1-oxyl (71051-83-7) → 2,5-Dihydro-3-<3-(4-hydroxy-3-nitrophenyl)-3-oxo-1-propenyl>-2,2,5,5-tetramethyl-1H-pyrrol-1-yloxyl radical (124558-44-7)

Guidance literature:

Multi-step reaction with 3 steps

1: 77 percent / 10percent aq. NaOH / ethanol / 3 h / 25 °C

2: 52 percent / conc. H₂SO₄, 67percent HNO₃ / 1 h / 0 °C

3: 74 percent / 50percent aq. NaOH / dioxane / 2 h / Heating

With sodium hydroxide; sulfuric acid; nitric acid; In 1,4-dioxane; ethanol;

DOI:10.1055/s-1989-27306

upstream raw materials:

C₁₇H₂₀NO₃

2,5-Dihydro-3-<3-(4-fluoro-3-nitrophenyl)-3-oxo-1-propenyl>-2,2,5,5-tetramethyl-1H-pyrrol-1-yloxyl radical

3-formyl-2,2,5,5-tetramethyl-pyrroline-1-oxyl

1-(4-fluorophenyl)ethanone

Downstream raw materials:

2,5-Dihydro-3-<3-(4-hydroxy-3,5-dinitrophenyl)-3-oxo-1-propenyl>-2,2,5,5-tetramethyl-1H-pyrrol-1-yloxyl radical