1019-52-9

Usage

Uses

Used in Pharmaceutical Industry:
3,5-Dinitro-4-hydroxybenzoic acid is used as a chemical intermediate for the preparation of benzamide derivatives, which serve as corticotropin-releasing factor (CRF) receptor antagonists. These antagonists are important in the development of medications targeting stress-related disorders and anxiety, as they help modulate the activity of the CRF system, which plays a crucial role in the body's stress response.

InChI:InChI=1/C7H4N2O7/c10-6-4(8(13)14)1-3(7(11)12)2-5(6)9(15)16/h1-2,10H,(H,11,12)/p-2

Upstream product

• 3681-93-4 vitexin 
• 577-52-6 4-bromo-3,5-dinitrobenzoic acid 
• 7221-27-4 4-amino-3,5-dinitrobenzoic acid 
• 393-77-1 α,α,α-Trifluoro-2,6-dinitro-p-cresol 
• 85365-92-0 3,5-dinitro-4-methoxybenzoic acid 
• 861298-98-8 4-methoxy-3,5-dinitro-benzoic acid amide 
• 33927-05-8 methyl 3,5-dinitro-4-hydroxybenzoate 
• 529-53-3 scutellarein 
• 163205-74-1 2-hydroxyl-5-carboxylbenzenesulfonic acid 
• 99-96-7 4-hydroxy-benzoic acid 
• 520-36-5 5,7-dihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one 
• 7697-37-2 nitric acid 
• 7664-93-9 sulfuric acid 
• 871896-81-0 4-(methyl-nitro-amino)-3,5-dinitro-benzoic acid methyl ester 

Downstream Products

• 33927-05-8 methyl 3,5-dinitro-4-hydroxybenzoate 
• 34384-49-1 4-hydroxy-3,5-dinitro-benzoic acid propyl ester 
• 135252-15-2 3,5-diamino-4-hydroxy-benzoic acid 
• 1071553-39-3 3-amino-4-hydroxy-5-nitro-benzoic acid methyl ester 
• 357332-77-5 4-hydroxy-3,5-dinitrobenzoyl chloride 
• 1443011-81-1 C₁₈H₁₇N₃O₂ 
• 1443011-82-2 C₁₁H₁₅N₃O₂ 
• 1443011-75-3 3,5-bis[(furan-2-ylmethyl)amino]-4-hydroxy-N-(naphthalen-2-ylmethyl)benzamide 
• 1443011-76-4 {4-hydroxy-3,5-bis[(thiazol-2-ylmethyl)amino]phenyl}(pyrrolidin-1-yl)methanone 
• 1443011-78-6 4-hydroxy-N-(naphthalen-2-ylmethyl)-3,5-dinitrobenzamide 
• 1443011-79-7 (4-hydroxy-3,5-dinitrophenyl)(pyrrolidin-1-yl)methanone 
• 54321-79-8 4-amino-3,5-dinitrobenzamide 
• 267014-44-8 3-amino-4-hydroxy-5-nitro-benzoic acid 

Relevant academic research and scientific papers

Trichloroisocyanuric Acid/NaNO2/wet SiO2 as an Efficient System for the Selective Dinitration of Phenols under Solvent-free Conditions

Dinitrophenols can be obtained via direct nitration of phenols with trichloroisocyanuric acid, NaNO2 and wet SiO2 at room temperature under solvent-free conditions with moderate to high yields.

NOVEL WATER SOLUBLE POLYIMIDE RESIN, ITS PREPARATION AND USE

The present invention relates to a novel water soluble polyimide resin, which contains a hydrophilic functional group such as —OH, —COOH to increase the solubility of the polyimide resin in alkali aqueous solution, and is suitable for using as an insulation film in electronic and photoelectric products. The present invention also relates to preparation and use of the above polyimide.

PEG-N2O4: An efficient nitrating agent for the selective mono- and dinitration of phenols under mild conditions

N2O4 was easily impregnated on polyethyleneglycol to give a stable reagent. The polyethyleneglycol-N2O4 (PEG-N2O4) system was used as an effective nitrating agent for the nitration of phenols. Mono- and dinitrophenols can be obtained via direct nitration of phenols in the presence of PEG-N2O4 at room temperature in moderate to high yields. Copyright Taylor & Francis Group, LLC.

Micellar ctalysis of organic reactions. XXXVIII:. A study of the catalytic effect of micelles of 3-hydroxymethyl-1-tetradecylpyridinium bromide on amide hydrolysis and nucleophilic aromatic substitution

The preparation of 3-hydroxymethyl-1-tetradecylpyridinium bromide and its use as a catalyst of nucleophilic aromatic substitution and also amide hydrolysis are reported. It was found that the hydroxydehalogenation of nitro-activated aryl halides was much faster in these micelles than in the presence of cetyl(2-hydroxyethyl)dimethylammonium bromide. It was concluded that the increased catalysis of nucleophilic aromatic substitution by this micelle was due to a faster decomposition of the aryl micellar ether which must occur before the phenolate product is released. No such difference in the two micelles was found for amide or thioamide hydrolysis since in these reactions the product amine is produced in the first step of the reaction and decomposition of the acylated micelle is not required in the rate-determining step of the reaction.

The Effects of Single- and Twin-Tailed Ionic Surfactants on the Hydroxy- dehalogenation of Charged Substrates

Reactions of OH- with 4-chloro-3,5-dinitrobenzoic and 2-chloro-3,5-dinitrobenzoic acids have been examined in solutions of cetyltrimethylammonium chloride, bromide and hydroxide, bis(dodecyl)dimethylammonium chloride, and bis(tetradecyl)dimethylammonium chloride.Rate effects were analysed quantitatively in terms of the distribution of reactants between water and the colloidal particles.It has been found that twin-tailed ionic surfactants better distinguish between favourable and unfavourable orientations of substrate molecules within micellar aggregates than do single-tailed ionic surfactants.

Micellar Catalysis of Organic Reactions. 29. SNAr Reactions with Neutral Nucleophiles

The reaction of a number of nitroactivated halobenzoates (1-4) with some primary and tertiary amines has been studied in the presence of micelles of cetyltrimethylammonium bromide (CTAB) and in water.With primary amines aminodehalogenation was observed, and it was found that if the reaction center of the aromatic substrate was located at the micelle water interface (compounds 1 and 2) the reaction was catalyzed by CTAB, but if the reaction center was more deeply buried into the micelle interior the reaction with aniline was inhibited by micelles of CTAB (compounds 3 and 4), while CTAB had little effecton the reaction of n-propylamine with compound 4.With the more sterically bulky tertiary amines, hydroxydehalogenation was observed rather than aminodehalogenation, and the reactions were all catalyzed by CTAB, but for the substrate with a more deeply buried reaction center (compound 4), the catalysis was stronger than for that with a reaction center at or near the interface (compound 2).The mechanism of hydroxydehalogenation was found to be specific base catalysis by the tertiary amine.Thus, the observation of micellar catalysis or inhibition of these reactions depends on the orientation of the organic substrate within the micellar aggreagate and the reaction product, amine or phenol, depends on the streric bulk of the amine at least for the compounds investigated here which contain two substituents ortho to the reaction center.

Synthesis of 3-Substituted 2,5-Dihydro-2,2,5,5-tetramethyl-1H-pyrrol-1-yloxyl Radicals, Useful for Spin-Labelling of Biomolecules

Synthesis and some reactions of 3-substituted 2,5-dihydro-2,2,5,5-tetramethyl-1H-pyrrol-1-yloxyl radicals (nitroxyl radicals, nitroxides) activated with carbonyl, cyano, or ester electron-withdrawing groups have been described.These compounds are useful new SH-reagents for spin-labelling of biomolecules.

AERVANONE, A NEW FLAVANONE FROM AERVA PERSICA

Key Word Index -- Aerva persica; Amaranthaceae; flavanone; C-glycoside; 8-galactosyl-7,4'-dihydroxyflavanone.