(R)-(+)-α-<(tert-butyldimethylsilyl)oxy>-4-methoxybenzeneacetonitrile

Base Information

• Chemical Name: (R)-(+)-α-<(tert-butyldimethylsilyl)oxy>-4-methoxybenzeneacetonitrile
• CAS No.: 120390-76-3
• Molecular Formula: C₁₅H₂₃NO₂Si
• Molecular Weight: 277.439
• Mol file: 120390-76-3.mol

Synonyms:(R)-(+)-α-<(tert-butyldimethylsilyl)oxy>-4-methoxybenzeneacetonitrile

Chemical Property of (R)-(+)-α-<(tert-butyldimethylsilyl)oxy>-4-methoxybenzeneacetonitrile

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-(+)-α-<(tert-butyldimethylsilyl)oxy>-4-methoxybenzeneacetonitrile

There total 6 articles about (R)-(+)-α-<(tert-butyldimethylsilyl)oxy>-4-methoxybenzeneacetonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

(R)-(+)-α-Hydroxy-4-methoxybenzeneacetonitrile (97070-73-0) + tert-butyldimethylsilyl chloride (18162-48-6) → (R)-(+)-α-<(tert-butyldimethylsilyl)oxy>-4-methoxybenzeneacetonitrile (120390-76-3)

Guidance literature:

With 1H-imidazole; In N,N-dimethyl-formamide; for 1h; Ambient temperature;

DOI:10.1016/S0040-4020(01)85686-6

Reference yield: 71.0%

1H-imidazole (288-32-4) + 4-methoxymandelonitrile (33646-40-1) + tert-butyldimethylsilyl chloride (18162-48-6) → (R)-(+)-α-<(tert-butyldimethylsilyl)oxy>-4-methoxybenzeneacetonitrile (120390-76-3)

Guidance literature:

In water; N,N-dimethyl-formamide;

Reference yield:

t-butyldimethylsiyl triflate (69739-34-0) + acetoxy-(4-methoxy-phenyl)-acetonitrile (99843-19-3) → (R)-(+)-α-<(tert-butyldimethylsilyl)oxy>-4-methoxybenzeneacetonitrile (120390-76-3) + (R)-(-)-2-acetoxy-2-(4-methoxyphenyl)acetonitrile + (S)-(-)-α-[(tert-butyldimethylsilyl)oxy]-α-(4-methoxyphenyl)acetonitrile

Guidance literature:

acetoxy-(4-methoxy-phenyl)-acetonitrile; With propan-1-ol; Candida antarctica lipase B; In toluene; at 60 ℃; for 3h;

t-butyldimethylsiyl triflate; With lutidine; In toluene; at 20 ℃; for 3h; Further stages. Title compound not separated from byproducts.;

DOI:10.1002/1099-0690(200205)2002:9<1516::AID-EJOC1516>3.0.CO;2-C

upstream raw materials:

(R)-(+)-α-Hydroxy-4-methoxybenzeneacetonitrile

tert-butyldimethylsilyl chloride

t-butyldimethylsiyl triflate

acetoxy-(4-methoxy-phenyl)-acetonitrile

Downstream raw materials:

2-amino-1-(4-methoxyphenyl)propan-1-ol

(R)-(-)-4-methoxy-mandelimidate HCl

methyl (R)-2-hydroxy-2-(4-methoxyphenyl)acetate

(1R,2S)-(-)-2-Amino-1-(4-methoxyphenyl)-2-phenyl-1-ethanol